Nippon Kayaku Kabushiki Kaisha

Takara Shuzo Co., Inc.

Takeji Sakasai

Hideo Sugimura

Akira Shiozawa

Kazuhisa Narita

Kazuo Ohtsuki

Hirotaka Yamamoto

Shuji Kurashige

Yoshihisa Umeda

Michio Ishikawa

Kyuichi Nemoto

Tsugio Tomiyoshi

Giichi Izumi

Katsuhiko Sakitama

Keiko Watanabe

Tetushi Saino

A process for producing an optically active aminoketone derivative having a central muscle relaxant activity is described wherein a racemic mixture of the aminoketone is reacted with optically active L-acetylphenylglycine and then isolating the optically active L-aminoketone from the diastereomeric salts formed by the reaction.

Process for producing an optically active aminoketone derivative

A new class of aminoketone derivatives according to the formula: ##STR1## and certain propiophenone derivatives in particular, corresponding to the formula: ##STR2## having central muscle relaxant activity.

Derivatives of an aminoketone

The present invention provides a use for the preparation of an immunopotentiator of a spergualin-related compound represented by the following general formula [I] or a pharmacologically acceptable salt thereof: ##STR1## wherein X represents ##STR2## or --(CH.sub.2).sub.n --, Y represents a hydrogen atom or a hydroxyl or hydroxymethyl group,

Immunopotentiator and spergualin-related compound therefor

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Urawa, Japan

Takeji Sakasai