Amino Up Chemical Co., Ltd.

Kansai Medical University

The Ritsumeikan Trust

Amino Up Co., Ltd.

Takehito Miura

Mikio Nishizawa

Tadayoshi Okumura

Yasuo Kamiyama

Koji Wakame

Buxiang Sun

Lan Yuan

Ken-ichi Kosuna

Yukinobu Ikeya

A compound is represented by Formula (I) or (II) described below. A medicine includes, as an active ingredient, a compound represented by Formula (I), (II), or (III) described below. 

Compound, medicine, anti-inflammatory, cosmetic, food and drink, and method for producing compound

The invention relates to sense oligonucleotide having a sequence complementary to a single-stranded RNA (antisense transcript) having a sequence complementary to mRNA of iNOS gene in order to control expression of iNOS (inducible nitric oxide synthase). The sense oligonucleotide of the present invention can control expression of iNOS and is useful for biological defense and treatment and prevention of diseases related to excessive production of NO, such as cancerogenesis, inflammatory disease, endotoxin shock by bacterial infection and the like.

Sense oligonucleotide capable of controlling the expression of INOS and composition comprising the same

The invention relates to a method of intracellularly controlling amounts of gene products, which can increase an amount of gene product intracellularly, comprising a step of introducing into the cell a substance having a sequence complementary to the base sequence of mRNA corresponding to the gene product, its precursor or another substance which can have equivalent action in the cell.

Method for controlling the amount of gene product, and agent for controlling the amount of gene product

Sense oligonucleotide capable of controlling the expression of iNOS and composition comprising the same

A novel substance that has the physiological activity of the aglycone of isoflavones and the physiological activity of the culture of the basidiomycetes with the physiological activities being synergistically enhanced, obtained by cultivating a basidiomycetes having a &#x3b2;-glucosidase activity in a medium containing an isoflavone, a method for producing it, and food, feedstuff and medicine containing it. The substance of the invention is improved in the physiological effect of the aglycone of isoflavones and the physiological effect of the culture of the basidiomycetes, and is not only useful as an anti-tumor agent but also is useful for therapy and/or prevention of osteoporosis and also as an immune enhancement agent.

Substance derived from basidiomycetes culture, method for producing it and its use

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Sapporo, Japan

Takehito Miura