Nissan Chemical Industries Limited

Kyushu University

Kyoto University

Nissan Chemical Corporation

Institute of National Colleges of Technology, Japan

National Institute of Technology

Takehisa Iwama

Nobuhide Miyachi

Takayuki Imoto

Taito Nishino

Masahiro Goto

Koichiro Saruhashi

Masato Horikawa

Masahiro Gotoh

Tatsuro Kanaki

Tatsuo Maruyama

Misayo Tomura

Daisuke Koda

Norio Nakatsuji

Hisato Hayashi

Misao Miyamoto

Ayako Otani

Keigo Matsumoto

Tomomi Otsuji

Keizo Tanikawa

Yoshimasa Kamikawaji

Tsubasa Kashino

Ayako Aihara

Mitsuaki Hirotsuka

Hiroharu Kawahara

Satoru Kidoaki

Yoichiro Fujita

Misayo Otani

Akiko Yamamoto

Yukie Tuji

Nobuhide Miyaji

Daisuke Kohda

A transdermally absorbable base material including: a lipid peptide compound including at least one of compound of Formula (1) below and the similar compounds or pharmaceutically usable salts thereof; a surfactant; a specific polyhydric alcohol; a fatty acid; and water, wherein Ris a Caliphatic group; Ris a hydrogen atom or a Calkyl group that optionally has a branched chain having a carbon atom number of 1 or 2; Ris a &#x2014;(CH)&#x2014;X group; n is a number of 1 to 4; and X is amino group, guanidino group, &#x2014;CONHgroup, or a 5-membered cyclic group optionally having 1 to 3 nitrogen atoms, a 6-membered cyclic group optionally having 1 to 3 nitrogen atoms, or a condensed heterocyclic group constituted by a 5-membered cyclic group and a 6-membered cyclic group which optionally have 1 to 3 nitrogen atoms.

Transdermally absorbable base material containing lipid peptide compound

The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the like.

Culture medium composition and method of culturing cell or tissue using thereof

The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition having an effect of preventing sedimentation of cells and/or tissues, which is afforded by substantially retaining the cells and/or tissues without substantially increasing the viscosity of the solution by nanofibers which have been added to the solution and uniformly dispersed in the liquid medium, and the like.

Culture medium composition

There is provided a dispersion containing a lipid peptide type compound useful as a low molecular weight gelator and a solvent capable of dissolving the lipid peptide type compound at a lower temperature. There is provided also a dispersion from which a hydrogel can be formed by a simpler method and from which a gel can be obtained as a gel having high thermal stability, and provide a method for forming the gel. A dispersion including a lipid peptide type compound in which a peptide portion having an amino acid repeating bonding structure is bonded to a lipid portion consisting of a Caliphatic group; and at least one alcohol selected from the group consisting of 1,2-alkanediol, 1,3-alkanediol, and ethylene glycol monoalkyl ether or a mixed solution of the at least one alcohol and water; and a method for producing a hydrogel by use of the dispersion.

Dispersion and method for forming hydrogel

A culture method (a preservation method) of somatic stem cells does not use a chemical such as DMSO that affects a differentiation function of somatic stem cells. A material for an undifferentiated state-maintaining culture for a somatic stem cell, having a naturally occurring polysaccharide; a culture liquid in which the material for the undifferentiated state-maintaining culture is dispersed; a somatic stem cell-containing culture liquid in which the somatic stem cell is suspended in the culture liquid; and a culture method for mesenchymal stem cells in which a naturally occurring polysaccharide is used.

Material for undifferentiated state-maintaining culture

The present invention relates to a protein production accelerating agent that has enabled to largely increase the produced amount of a desired protein by adding polysaccharides to a medium for animal cells containing a serum or serum alternative, and a production method of a protein using a medium containing the protein production accelerating agent.

Enhancing ingredients for protein production from various cells

There is provided a cosmetic additive in which the cosmetic obtained by mixing has excellent transparency, and good spread and feeling of use during application, and stickiness when dried can be suppressed, and a cosmetic containing the additive. A cosmetic additive containing cellulose fibers having an average fiber diameter (D) of 0.001 to 0.05 &#x3bc;m, and a ratio (L/D) of average fiber length (L) to average fiber diameter (D) of 5 to 500; and a cosmetic containing the cosmetic additive.

Cosmetic composition comprising cellulose fibers with small fiber diameter and comparatively small aspect ratio

There is provided a production method of a cosmetic, a preparation method of a gel for cosmetics, and a method of reducing the use amount of a polymer thickener blended in cosmetic raw materials. The present invention relates to a production method of a cosmetic comprising blending, into the cosmetic raw material in addition to the polymer thickener, at least one lipid peptide-type gelator that contains a low-molecular lipid peptide or a pharmaceutically usable salt thereof at a ratio of 0.1% by weight to 0.5% by weight based on a mass of the polymer thickener to form a thickening gel; a preparation method of a gel for cosmetics comprising blending, into an aqueous medium for cosmetics, a polymer thickener and at least one lipid peptide-type gelator that contains a low-molecular lipid peptide or a pharmaceutically usable salt thereof at the above-mentioned ratio to form a gel; and a method of reducing the use amount of a polymer thickener in production of a cosmetic comprising blending, into the cosmetic raw material in addition to the polymer thickener, at least one lipid peptide-type gelator that contains a low-molecular lipid peptide or a pharmaceutically usable salt thereof at the above-mentioned ratio.

Production method of cosmetic, preparation method of gel for cosmetics, and method of reducing use amount of polymer thickener blended in cosmetic raw materials

It is an object of the present invention to provide a cosmetic or external skin preparation that has an improved feel in use, e.g., excellent stretching on the skin surface, excellent permeation into the skin, and no stickiness, or crinkles. A cosmetic or an external skin preparation, and a medical instrument, comprising at least one lipid peptide-based gelator that contains a low-molecular lipid peptide of Formula (1): (where Rto Rare independently an organic group) or a pharmaceutically usable salt thereof.

Cosmetic, external skin preparation, and medical instrument

There is provided a gel sheet that has high biocompatibility and safety, can contain both a hydrophilic medicinal agent and a hydrophobic medicinal agent, and provides an excellent feel in use during the application onto human skin or others. A gel sheet including: a lipid peptide gelator including a low molecular weight lipid peptide having a molecular weight of 1,000 or less or a pharmaceutically usable salt of the lipid peptide; and a polymeric compound, wherein the polymeric compound is included in an amount of more than 1% (w/w) and less than 50% (w/w) with respect to the total mass of the gel sheet.

Gel sheet containing lipid peptide gelator and polymeric compound

A spray base material containing an aqueous medium that is gelled by a low-molecular gelator in the medium, wherein the low-molecular gelator includes one or more compounds selected from low-molecular compounds capable of gelling the aqueous medium via self-assembly.

Spray base material including low-molecular gelator

There is provided a gelator that is capable of forming a gel by an extremely small amount of addition in a wide pH range from acidic to alkaline regions, and a gel having high environmental compatibility, biocompatibility, and biodegradability. A gelator comprising: a lipid peptide of Formula (1) wherein Ris a Caliphatic group, Ris a hydrogen atom or a Calkyl group optionally having a Cbranched chain, Ris a &#x2014;(CH)&#x2014;X group, n is a number from 1 to 4, and X is an amino group, a guanidino group, a &#x2014;CONHgroup, or a 5-membered ring optionally having 1 to 3 nitrogen atoms, a 6-membered ring optionally having 1 to 3 nitrogen atoms, or a fused heterocycle including a 5-membered ring and a 6-membered ring that optionally has 1 to 3 nitrogen atoms); or a pharmaceutically usable salt of the lipid peptide.

Lipid dipeptide and gel

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Funabashi, Japan

Takehisa Iwama