Meiji Seika Kaisha, Ltd.

Ando Electric Company

Takehiro Yamamoto

Tetsuya Matsushima

Kiyoaki Katano

Kenichi Fushihara

Chika Kikuchi

Kenichi Kanemoto

Masaharu Shiotani

Kazue Sasaki

Naoto Ohkura

Yukiko Hiraiwa

Shigeki Suzuki

Yuuko Nakatani

Mieko Nagasawa

Kokichi Suzuki

Chizuko Kuroda

Eriko Satoh

Takao Inoue

Disclosed are compounds represented by formula (I) which have triglyceride biosynthesis inhibitory activity in the liver and inhibitory activity against the secretion of apolipoprotein B-containing lipoprotein from the liver and particularly have excellent inhibitory activity against the secretion of apolipoprotein B-containing lipoprotein, are free from side effect of accumulation of lipids in the liver, and are useful for the treatment and prevention of hyperlipidemia and arteriosclerotic diseases. In formula (I), Rand Rrepresent alkyl, alkoxy, cycloalkyl, phenyl, alkenyl, alkynyl, or a five- or six-membered saturated or unsaturated heterocyclic ring, or Rand R, together with a nitrogen atom to which Rand Rare attached, may form a ring; Rand Rrepresent a hydrogen atom, alkyl, a halogen atom, hydroxyl, nitrile, alkoxycarbonyl, alkoxy, or carboxyl; or Rand Rmay be attached to each other to form &#x2014;(CH)&#x2014;, &#x2014;N&#x2550;CH&#x2014;, &#x2014;CH&#x2550;N&#x2014;, or &#x2014;(Calkyl)C&#x2550;N&#x2014;; A, D, E, and G each represent a carbon atom, or any one of A, D, E, and G represents a nitrogen atom with the other three each representing a carbon atom; Q represents a nitrogen atom or a carbon atom; Y represents a group represented by formula (II) wherein X represents a hydrogen atom, group &#x2014;C(&#x2550;O)N(R)Ror group &#x2014;C(&#x2550;O)OR, Ris absent or represents a bond, an oxygen atom, a sulfur atom, &#x2014;SO&#x2014;, &#x2014;SO&#x2014;, &#x2014;CH&#x2014;CH&#x2014;, or &#x2014;CH&#x2550;CH&#x2014;, and Rand Rrepresent a hydrogen atom, alkyl, alkoxy, a halogen atom, or hydroxyl; and Z represents &#x2014;(CH)&#x2014;, &#x2014;O&#x2014;(CH)&#x2014;, or &#x2014;C(&#x2550;O)NH&#x2014;(CH)&#x2014;

Nitrogen-containing heterocyclic compounds and benzamide compounds and drugs containing the same

Disclosed are compounds represented by formula (I) which have triglyceride biosynthesis inhibitory activity in the liver and inhibitory activity against the secretion of apolipoprotein B-containing lipoprotein from the liver and particularly have excellent inhibitory activity against the secretion of apolipoprotein B-containing lipoprotein, are free from side effect of accumulation of lipids in the liver, and are useful for the treatment and prevention of hyperlipidemia and arteriosclerotic diseases. In formula (I), R and R represent alkyl, alkoxy, cycloalkyl, phenyl, alkenyl, alkynyl, or a five- or six-membered saturated or unsaturated heterocyclic ring, or R and R , together with a nitrogen atom to which R and R are attached, may form a ring; R and R represent a hydrogen atom, alkyl, a halogen atom, hydroxyl, nitrile, alkoxycarbonyl, alkoxy, or carboxyl; or R and R may be attached to each other to form &mdash;(CH ) &mdash;, &mdash;N&boxH;CH&mdash;, &mdash;CH&boxH;N&mdash;, or &mdash;(C alkyl)C&boxH;N&mdash;; A, D, E, and G each represent a carbon atom, or any one of A, D, E, and G represents a nitrogen atom with the other three each representing a carbon atom; Q represents a nitrogen atom or a carbon atom; Y represents a group represented by formula (II) wherein X represents a hydrogen atom, group &mdash;C(&boxH;O)N(R )R or group &mdash;C(&boxH;O)OR , R is absent or represents a bond, an oxygen atom, a sulfur atom, &mdash;SO &mdash;, &mdash;SO&mdash;, &mdash;CH &mdash;CH &mdash;, or &mdash;CH&boxH;CH&mdash;, and R and R represent a hydrogen atom, alkyl, alkoxy, a halogen atom, or hydroxyl; and Z represents &mdash;(CH ) &mdash;, &mdash;O&mdash;(CH ) &mdash;, or &mdash;C(&boxH;O)NH&mdash;(CH ) &mdash;.

Nitrogen-containing heterocyclic compounds and benamide compounds and drugs containing the same

Phosphonic acid derivative having inhibitory activity against carboxypeptidase B

A data processing apparatus and a data processing method easily realizable of a transparent processing of a high-speed serial data. The data processing apparatus ( ) including a serial data conversion section for converting serial data to predetermined set of parallel data; a transparent data information detection section ( ) for detecting information concerning transparent data, from the parallel data; an effective byte number operation section for operating an effective byte number of the parallel data; a transparent data conversion section ( ) for converting transparent data of the parallel data, and moving predetermined data after the transparent data forward, in the parallel data; an address control section ( ) for determining addresses at which the parallel data are rearranged; and a data array section ( ) for moving predetermined data to one predetermined set of parallel data from another predetermined set of parallel data.

Data processing apparatus and data processing method

Phosphonic acid derivatives having carboxypeptidase b inhibitory activity

Growing community of inventors

Yokohama, Japan

Takehiro Yamamoto