Kyowa Hakko Kogyo Co., Ltd.

Takehiro Ogasa

Tadashi Hirata

Yukio Hashimoto

Shigeru Kobayashi

Masaji Kasai

Kiyoshi Sato

Ikuo Matsukuma

Kazuo Kimura

Hiromitsu Saito

Junichi Shimada

Ryo Okachi

Kenichi Mochida

Akira Sato

Seigo Takasawa

Yukiteru Mimura

Shinji Tomioka

Masahiko Kinugawa

Chikara Murakata

Hitoshi Arai

Nobuhiro Nakamizo

Yoshiaki Masuda

Hiroshi Nishikawa

Takashi Mimura

Sachiko Kato

Takahiro Imai

Tadahi Hirata

Eiichiro Imai

Iwao Chujo

Provided is a process for efficiently producing N-glycyltyrosine of high purity represented by the following formula:

Process for producing N-glycyltyrosine and its crystal structure

The present invention relates to glutathione monoester sulfonate represented by formula (I): ##STR1## (wherein R.sup.1 represent lower alkyl, and R.sup.2 represents lower alkyl, or substituted or unsubstituted aryl) which readily crystallizes and has high stability, and a simple process for producing the same. According to the process, the product having high purity can be obtained in high yields.

Glutathione monoester sulfonate

Process for producing indolocarbazole derivatives

An indole derivative represented by formula (I): ##STR1## wherein R.sup.1 is a lower alkoxymethyl group or a formyl group, R.sup.2 is a lower alkyl group, R.sup.3 is a hydrogen atom or a lower alkyl group and R.sup.4 is a hydrogen atom or a lower alkyl group, which is useful as an intermediate for the synthesis of a compound, 5-aziridino-3-hydroxymethyl-l-methyl-2- (1H-indole-4,7-dione)prop-.beta.-ene-.alpha.-ol, which has antitumor activity.

Indole 3-carboxylic acid derivatives

Carbacephem and cephem compounds represented by the formula: ##STR1## [Wherein X is S or CH.sub.2 ; n is an integer of 1 to 5; R.sub.1 is an unsubstituted or substituted heterocyclic group (where the heterocyclic group is a 5- or 6-membered heterocyclic group having 1 to 4 of O, S and N); R.sub.2 is a group represented by the formula: ##STR2## (where R.sub.4 is an unsubstituted or substituted phenyl or 2-aminothiazolyl) or a group represented by the formula: ##STR3## (where R.sub.5 is an unsubstituted or substituted lower alkyl); R.sub.3 is hydrogen, an alkali metal, an alkaline earth metal, an organic ammonium group or an ester residue, and R.sub.1 may be a quaternary ammonium group, where --CO.sub.2 R.sub.3 represents --CO.sub.2.sup.- ] have strong antibacterial activity against Gram-positive and Gram-negative bacteria, and are useful for treating various infections.

3-heteroaralkylthio carbacephem compounds and antibacterial

Disclosed are optically active acylated cephalosporin analogs which are useful as antibacterial agents and methods for preparing such compounds.

Optically active carbacephems

Optically active cephalosporin analogs of the formula ##STR1## wherein R.sub.2 represents a hydrogen or a group represented by the formula ##STR2## wherein R.sub.3 is a straight or branched lower alkyl group having 1 to 6 carbon atoms, a straight or branched lower alkoxy group having 1 to 6 carbon atoms or a phenyl group and R.sub.4 is a hydrogen or a straight or branched lower alkyl group having 1 to 6 carbon atoms; and A.sub.2 represents a straight or branched lower alkyl group having 1 to 6 carbon atoms or a straight or branched lower alkyl group having 1 to 6 carbon atoms which is substituted with one or two carboxyl groups, are useful as antibacterial agents.

Optically active cephalosporin analogs

Carbacephem compounds represented by the formula: ##STR1## [wherein R.sub.1 is a lower alkylsulfonyloxy, unsubstituted or substituted arylsulfonyloxy, azido, cyano, carbamoyloxy, unsubstituted or substituted heterocyclic thio ('heterocyclic' means a 5- or 6-membered heterocyclic group having 1 to 4 O, S or N atoms), unsubstituted or substituted lower alkylthio, or unsubstituted or substituted arylthio group; R.sub.2 and R.sub.3 are groups frequently used in the cephalosporin chemistry] have strong antibacterial activity against Gram-positive and Gram-negative bacteria, and are useful for curing various infections.

3-substituted carbacepem compounds having antibacterial effect

Optically active cephalosporin analogs are produced by an optically selective acylation reaction. The reaction is carried out in the presence of a microbial enzyme which catalyzes the selective optical acylation. The products thus obtained are useful as antibacterial agents.

Process for producing cephalosporin analogs

Optically active cephalosporin analogs are produced by optically selective deacylation of an optically inactive acylated analog. The compounds are useful as intermediates in the preparation of optically active acylated antimicrobial agents.

Process for producing optically active cephalosporin analogs

Disclosed are optically active cephalosporin analogs which are produced by optically selective deacylation of an optically inactive acylated analog. The compounds are useful as intermediates in the preparation of optically active acylated antimicrobial agents.

Process of producing optically active cephalosporin analogs by enzyme

Novel cephalosporin analogs are disclosed which are useful as intermediates in the production of other compounds having antibacterial activity. Methods for producing the compounds are also disclosed.

Growing community of inventors

Machida, Japan

Takehiro Ogasa