Asahi Kasei Kogyo Kabushiki Kaisha

Takehiro Koshio

Tatsuro Fujiwara

Masao Yaso

Satoshi Shuto

Hiromichi Itoh

Takumi Obara

A compound of the formula ##STR1## wherein A is adenine-9-yl and X is halogen, Preferably iodine, or a pharmaceutically acceptable salt thereof. It is a novel derivative of neplanocin A and has almost the same level of cytotoxic activity. However, it is not inactivated by the action of adenosine deaminase. It is produced by replacing a hydroxyl at position-6' in neplanocin A or 2', 3'-O-protected neplanocin A with halogen by use of a halogenating agent, and when hydroxyl at position-2' or -3' is protected, removing the protective group thereof.

Growing community of inventors

Shizuoka, Japan

Takehiro Koshio