Daiichi Sankyo Company, Limited

Other

Takehiro Fukuzaki

Hideki Kobayashi

Kenjiro Ueda

Masahiro Konishi

Takeshi Honda

Yumi Matsui

Yukari Onishi

Andrew G Myers

Makoto Mori

Akihiro Furukawa

Tetsuyoshi Matsufuji

Roger B Clark

Ziyang Zhang

Xiben Li

Wenying Wang

Yoshitaka Ichikawa

Wesley Francis Austin

Senkara Rao Allu

Jonathan F Lawrence

Udara Anulal Premachandra Ilandari Dewage

Sushmita D Lahiri

Tetuyoshi Matsufuji

Takayuki Momose

Susumu Satoh

Masanori Kuroha

Tsuyoshi Arita

Provided are macrolide compounds for the treatment of infectious diseases. The macrolides disclosed herein include 14-membered ketolides and 14-15-membered azaketolides, and may comprise modified sugars which are desosamine analogues. The disclosed macrolides may have a bicyclic structure. Also provided are pharmaceutical compositions and methods of treating infectious diseases, and in particular, disease which results from Gram negative bacteria using the disclosed macrolides. This disclosure additionally provides methods of preparing the macrolides by a strategy that enables late-stage modification of the 6'-position of the sugar moiety, thereby allowing facile access to previously difficult-to-make macrolide compounds.

Macrolides with modified desosamine sugars and uses thereof

The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein,

Phenylpyrrole derivative

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Tokyo, Japan

Takehiro Fukuzaki