Hitachi, Ltd.

Kanagawa Academy of Science and Technology

Japan Science and Technology Agency

Nippon Sheet Glass Company, Limited

The University of Tokyo

Institute of Microchemical Technology Co., Ltd.

Sony Corporation

Kabushiki Kaisha Toshiba

Yokogawa Electric Corporation

Hitachi Plant Technologies, Ltd.

Jfe Engineering Corporation

Kanagawa Institute of Industrial Science and Technology

Takehiko Kitamori

Manabu Tokeshi

Akihiko Hattori

Tsuguo Sawada

Jun Yamaguchi

Tetsuya Matsui

Masaharu Sakagami

Kazumichi Suzuki

Kenji Yokose

Kazuma Mawatari

Masataka Koga

Haruo Fujimori

Tsuyoshi Nishitarumizu

Masaharu Ueno

Akihide Hibara

Yutaka Kazoe

Arata Aota

Yuriy Pihosh

Toshihiko Nakata

Kenji Kitamura

Shu Kobayashi

Kazumichi Imai

Yukio Kembo

Yuichiro Mori

Yasushi Nomura

Kuniaki Okamoto

Shunsuke Uchida

Hideo Yusa

Takashi Nishi

Michihiro Ohnishi

Kazuhiko Nakano

Toshiaki Mizuno

Hajime Sudo

Tetsuo Fukasawa

Toshitsugu Ueda

Shigeki Yamazaki

Masahiro Kondo

Kazuo Yasuda

Akira Sasahira

Toshiyuki Tsuchiya

Satoru Kawasaki

Hidekazu Tsudome

Takahiro Nagata

Yukihiko Takamatsu

Hisao Takahara

Keita Tanaka

Masahiro Kuwata

Yoshihiro Ozawa

Masaaki Fujii

Mari Sasaki

Katsuhiko Ohsaki

Osamu Tabata

Yoshikuni Kikutani

Seiichi Naitou

Yuko Kihira

Keisuke Morishima

Jiaqi Wu

Kouichi Tsuji

A nano-fluidic device includes: a first substrate that has a nanoscale groove on one surface; and a second substrate that is integrally provided with the first substrate by bonding one surface of the second substrate to the one surface of the first substrate and forms a nanochannel with the groove of the first substrate, in which either the first substrate or the second substrate includes at least a thin portion in a part of a position overlapping the nanochannel in plan view, and the thin portion is deformed by pressing to open and close the nanochannel.

Nano-fluidic device and chemical analysis apparatus

A first proton-donating layer () is a layer having a proton-donative functional group on the surface, for example, a silicon oxide layer. A second proton-donating layer () is also a layer having a proton-donative functional group on the surface, for example, a silicon oxide layer. Negative surface charges are formed on the main surface section of a first base () and the main surface section of a second base (), and these negative charges increased the proton conductivity in an aqueous solution fed to a nano channel. Although, in the aqueous solution, proton migration through hopping between water molecules contributes to its diffusion, the negative charges formed on the main surfaces of the bases () attract protons in the aqueous solution, and the conduction of protons is efficiently achieved in 'high-speed transfer regions' formed in the vicinity of the proton-donating layers ().

Proton conductor and fuel cell

A functional device (and a functional device manufacturing method) includes a first substrate in which a groove is formed in one surface, a second substrate which is integrally disposed by bonding one surface of the second substrate to the one surface of the first substrate, and forms a flow path together with the groove of the first substrate, at least one modification object of a capture body which captures a target substance supplied into the flow path, an electrode which imparts an electrical or a chemical action to the target substance, and a catalyst, in which the modification object is disposed by being modified on a part of an inner surface of the flow path, a bonding portion between the one surface of the first substrate and the one surface of the second substrate is formed by bonding fluorine to silica.

Functional device and method of manufacturing the same

Provided is a microchip capable of integrating liquid evaporation as an operation on the microchip. In the microchiphaving a gas flow pathinside, liquid is dispersed by capillary action and pooled in a pool portionat a bottom of the gas flow path, and at least a part of the liquid pooled in the pool portionis evaporated. As the capillary action is used, the liquid can be dispersed and pooled in the pool portionat the bottom of the gas flow pathinside the microchip. Besides, the liquid pooled in the pool portionremains in the pool portion by a surface tension even if gas is made to flow in the gas flow pathor the gas flow path is evacuated for evaporation. This enables highly efficient evaporation inside the microchip

Microchip, microchip device, and evaporation operation method using the microchip

An apparatus for separating plasma by which plasma can be separated from a small amount of whole blood cell sample without centrifugation is disclosed. This apparatus includes a blood channel through which blood flows; and a plasma channel through which plasma separated from said blood flows. The plasma channel is arranged at least partially in parallel with said blood channel and the blood channel and the plasma channel are at least partially in contact with each other along the longitudinal direction of the channels. Blood is made to flow at a flow rate at which blood cell components in the blood flowing through the blood channel axially accumulate and at which hemolysis does not occur. The plasma moves to the plasma channel after being separated into a blood cell layer and a plasma layer.

Apparatus and method for separating plasma

A microchannel chip having a microchannel formed in a substrate and a gas-liquid phase separation microchannel whose upper part is covered with a porous film, the gas-liquid phase separation microchannel being connected to the downstream end of the microchannel and having a depth of 10 &#x3bc;m to 100 &#x3bc;m. Also, a gas-liquid phase separation method which is a method for separating a liquid-phase flow from a two-phase flow flowing through a microchannel by removing a gas phase, the two-phase flow composed of the gas phase and the liquid phase, which liquid phase flows in the periphery of the above-described microchannel and which gas phase flows interiorly of the liquid-phase flow.

Microchannel chip and method for gas-liquid phase separation using same

A new technical means is provided that can be produced and prepared at low cost, and in which the generation of stagnation in the flow of a liquid sample can be suppressed, microbeads can be smoothly and simply injected, filled and transported and the generation of dust can be also suppressed and a new extracting method for nucleic acid using the new technical means is provided. A microchip has a microchannel () formed by groove parts () provided in connecting surfaces of upper and lower substrates (). In the microchannel (), a gap part () in which the section of the channel is reduced is provided in a central part upward and downward, rightward and leftward, or upward and downward and rightward and leftward the section thereof, and microbeads are checked.

Microchip, nucleic acid extracting kit, and nucleic acid extracting method

A slide valve apparatus includes a first member having a first fluid channel for allowing a fluid to flow therethrough, a second member sliding along the first member and having a second fluid channel formed in a manner to communicate with the first fluid channel, and a first elastic membrane formed in the sliding surface along which the second member and the first member slide relative to each other and having a first communicating hole communicating with the first fluid channel. In manufacturing the slide valve apparatus, a gas is spurted from the open edge of the first fluid channel in at least a stage between the start up of the step of forming the elastic membrane and the end of the step of baking the elastic membrane so as to form in the elastic membrane the communicating hole communicating with the first fluid channel.

Slide valve apparatus and method of manufacturing slide valve apparatus

For enlarging the application range of samples capable of being treated, decreasing the amount of samples used, preventing deterioration of samples by a change with the passage of time and preventing mixing of samples by diffusion, a micro fluidics system according to the present invention comprises a sample server which stores plural samples and which has sample efflux portions, a microchip for feeding samples to a treating portion through plural sample introducing portions communicating with the sample efflux portions and further through a microchannel, allowing the samples to be subjected to a predetermined treatment, and a sample feeder for feeding the samples stored in the sample server to the sample introducing portions through the sample efflux portions. The sample feeder comprises valves for opening and closing communication paths between the sample efflux portions of the sample server and the sample introducing portions of the microchip and pressurizing devices for pressurizing the samples stored in the sample server and pushing them out into the sample introducing portions in an open condition of the valves.

Micro fluidics system and treating method using same

A method of catalytic reaction uses a micro-reactor () with a metal catalyst () or a metal complex catalyst () as a solid phase supported on the inner wall () of a channel (), a solution () dissolving a reactant as a liquid phase and hydrogen () as a gas phase are flown through the channel () in pipe flow state, and the reaction of the solution () and the gas () accelerated by the metal catalyst () or the metal complex catalyst () is conducted by three phase catalytic reaction of solid-liquid-gas phases. The metal catalyst () or the metal complex catalyst () is incorporated in a polymer, and hydrogenation reaction by three phase catalytic reductive reaction of a substance to be reduced can be conducted in short time at good yield. For hydrogenation reaction of unsaturated organics, the rate of reaction and yield are high when palladium catalyst is used, and carbonylation reaction can be conducted if carbon monoxide is used instead of hydrogen.

Method of catalytic reaction using micro-reactor

A plurality of elements can be analyzed simultaneously with high sensitivity using a microchip. The microchip () comprises a substrate (), a channel () formed in the substrate (), and an analyzing part () consisting of a part of flat surface of the substrate (), where the outlet of the channel () is formed as an opening () and measurement object liquid overflowed from the opening () stays on the flat surface of the substrate () to become a sample of analysis. The measurement object liquid is made to overflow as a sample of analysis to the analyzing part () using the microchip () and then the sample of analysis is preferably dried before a primary X-ray is made to enter under conditions of total reflection and fluorescent X-rays are detected.

Microchip and analyzing method and device employing it

An integrated structure of multilayer flow microchannel, which comprises a plurality of microchannels in which parallel multilayer flow that involves the interface of fluids is formed, arranged on various positions of a substrate, wherein each of the multilayer flow microchannels is communicated with another multilayer flow microchannel. A plurality of unit operations can be carried out continuously with high efficiency on a microchip, enabling high-degree microanalysis or precise chemical synthesis using the highly integrated structure of multilayer flow microchannel.

Method of operating an integrated structure of multilayer flow microchannel

A microchemical system is provided, which can improve the working efficiency of the user. In the microchemical system, a plate-shaped elementthat constitutes an optical unithas an optical wave guide path, which acts as an optical path for exciting light and detecting light. An irradiation lensis disposed at an end of the optical wave guide pathdownstream in the direction of travel of the exciting light and the detecting light, and a channelis located downstream of the irradiation lens, through which a liquid containing a sample flows. A detectoris disposed at an end of the plate-shaped elementdownstream of the channeland detects the detecting light for analysis of the sample.

Microchemical system and photothermal conversion spectroscopic analysis method implemented by the system

A small and portable microscope for ultramicroanalysis has an excellent spatial resolution and fixed position analyzing ability. The microscope has at least a part of an excitation light source, a part of a probe light source and a part of a thermal lens microscope optical system arranged integrally in a device body. The device body also includes an analyzing cell and substrates supporting the analyzing cell.

Thermal lens microscope device

It is an object to provide a photothermal conversion spectroscopic analysis method that enables measurement to be carried out with high sensitivity, and a photothermal conversion spectroscopic analysis apparatus that carries out the method. The photothermal conversion spectroscopic analysis apparatus is comprised of an exciting light source, a chopperthat is disposed close to the exciting light sourcein the optical path of exciting light emitted from the exciting light source, a mirrorthat changes the direction of travel of the exciting light, a detecting light source, a dichroic mirrorthat has detecting light from the detecting light sourceincident thereon and makes the exciting light and the detecting light coaxial, a lensthat has a suitable amount of chromatic aberration, and a holderthat holds the lenssuch as to enable adjustment along three axes.

Photothermal conversion spectroscopic analysis method, and photothermal conversion spectroscopic analysis apparatus for carrying out the method

Growing community of inventors

Tokyo, Japan

Takehiko Kitamori