Nippon Gohsei Kagaku Kogyo Kabushiki Kaisha

Takehiko Kakimoto

Kazumasa Hirata

Takeo Kawabata

Akira Taisha

Toshimi Ogawa

Toshima Ogawa

This invention provides a process for producing 2-alkyl-4-halo-5-formylimidazoles which includes halogenating 2-alkyl-5-formylimidazoles with a N-halosuccinimides in the presence of dioxane or mixture of dioxane and ethylene glycol monomethylether as solvent and in the presence of alkali metal hydrogen carbonate as catalyst, which are readily available, with good yield.

Process for producing 2-alkyl-4-halo-5-formylimidazoles

The invention provides a process for producing a 2-substituted-4-hydroxymethylimidazole easily and in good yield by means of simple equipment. This process comprises reacting hydroxymethylglyoxal, a monoaldehyde and ammonia in a sequence such that said monoaldehyde and ammonia are first reacted with each other and hydroxymethylglyoxal is then introduced into the reaction system for further reaction.

Process for production of 2-substituted-4-hydromethylimidazole compounds

A process for preparing an aminoacetaldehyde dialkyl acetal which comprises reacting a halogenoacetaldehyde dialkyl acetal with ammonia or an alkylamine in an aqueous medium in the simultaneous presence of an alkali metal hydroxide or of an alkaline earth metal hydroxide, and distilling the resulting reaction mixture.

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Gifu, Japan

Takehiko Kakimoto