Osaka University

Ehime University

Fujifilm Wako Pure Chemical Corporation

Takefumi Doi

Tatsuya Sawasaki

Kiyohito Yagi

Masuo Kondoh

Yosuke Hashimoto

Hiroyuki Takeda

Yoshiaki Okada

Tsuyoshi Inoue

Junichi Takagi

Atsushi Nakagawa

Kei Ohkubo

Hiroaki Adachi

Haruyasu Asahara

Naoyuki Miyazaki

Kenji Iwasaki

Mika Hirose

Keisuke Shirakura

Kohki Endo

Maki Tamura

The present invention provides a method for producing a substance with a modified carbon allotrope surface that can suppress or prevent uneven distribution, uneven orientation, and the like of a structural analysis target substance in a structural analysis by cryo-electron microscopy. A method for producing a substance with a modified carbon allotrope surface of the present invention includes: the step of surface-treating by reacting a carbon allotrope surface with a halogen oxide radical, wherein the carbon allotrope surface is modified by the surface-treating.

Method for producing substance with modified carbon allotrope surface, method for producing substance with carbon allotrope surface into which functional group is introduced, method for producing grid for cryo-electron microscopy, organic substance, and grid for cryo-electron microscopy

An object of the present invention is to provide a novel molecule which has high specificity to CLDN-5 and recognizes an extracellular domain of CLDN-5. The object is achieved by an antibody which specifically recognizes a three-dimensional structure or a primary structure of an extracellular domain of a Claudin-5 protein.

Anti-CLDN-5 antibody, and drug containing said antibody

Provided is a novel technique for controlling the blood-brain barrier. An antibody whose epitope is a region within an extracellular domain of Claudin 5 protein.

Claudin 5 antibody, and medicine containing said antibody

Growing community of inventors

Osaka, Japan

Takefumi Doi