Nissan Chemical Industries Limited

Takeaki Shoji

Keigo Matsumoto

Nobuyuki Kakiuchi

Tsubasa Kashino

Hiroki Yamaguchi

Kazuki Hirasada

Daiki Yamaguchi

There is provided a hydrogel-forming material from which a hydrogel can be formed with a simpler method and under milder conditions. A hydrogel-forming material comprising a lipid peptide-type gelator that is formed of at least one selected from compound of the following formula (1): where Ris a Caliphatic group; Ris a hydrogen atom or a Calkyl group which optionally has a Cbranched chain; Ris a &#x2014;(CH)&#x2014;X group; n is a number from 1 to 4; and X is an amino group, a guanidino group, a &#x2014;CONHgroup, or a 5-membered ring group or a 6-membered ring group, or a condensed ring group that contains a 5-membered ring and a 6-membered ring, optionally containing 1 to 3 nitrogen atoms, and the similar compounds or pharmaceutically usable salts thereof; water; and an additive including either an organic acid or an organic acid salt.

Hydrogel-forming material

There is provided a practical method for preparing lipopeptide compounds, which method is capable of inexpensive mass production without requiring complicated operations. The lipopeptide compound of formula (3): is produced by reacting an ester compound of formula (1): with an &#x3b1;-amino acid compound of formula (2): in the presence of a base and within a solvent containing a nonpolar organic solvent.

Method for preparing lipopeptide compound

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Funabashi, Japan

Takeaki Shoji