Daicel Chemical Industries, Ltd.

Koken Company, Limited

Takeaki Miyamoto

Hiraku Ito

Tohru Shibata

Teruo Miyata

Masayasu Furuse

Yasuharu Noishiki

Kazuhiko Kodaira

Hiroshi Inagaki

Anticoagulative high-molecular composition which comprises a cellulosic polyelectrolyte complex formed from a polycationic cellulose derivative such as a quaternary ammonium salt of hydroxyalkyl cellulose, and a polyanionic cellulose such as sodium cellulose glycolate, which is used in the field of medical instruments or devices.

Anticoagulative high-molecular compositions

This invention concerns a production process of an antithrombogenic and antiadhesive material which can favorably be used as artificial blood vessels, artificial valves, grafting patches for cardiovascular organs, artificial heart catheters and so on. The gist of this invention is constructed substantially of subjecting glycidyltrialkylammonium halide such as glycidyltrimethylammonium chloride to the reaction with a material comprising pure collagen or collagen and other components like mucopolysaccharide in order to introduce a cationic quaternary functional group in collagen molecules of the material and then subjecting heparin to the ionic combination with the cationic functional group introduced. Meanwhile, in advance of the above chemical treatment, the material is prepared from dog's blood vessel by removing proteins except collagen, from cow's Achilles tendon by crushing into powder, from human amnion by rinsing in distilled water or from polyester knit tube by coating its inside with powdered collagen, for example.

Production process of an antithrombogenic and antiadhesive material for

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Nagaokakyo, Japan

Takeaki Miyamoto