Kanto Kagaku Kabushiki Kaisha

Nagoya Industrial Science Research Institute

Hokkaido University

Takeaki Katayama

Kunihiko Murata

Kunihiko Tsutsumi

Ryoji Noyori

Takeshi Ohkuma

Noriyuki Utsumi

Masahito Watanabe

Noriyoshi Arai

Toshihide Takemoto

Takeshi Okuma

Methods are provided for producing an optically active secondary alcohol at a high optical purity by hydrogenating a substrate carbonyl compound at a high efficiency using as a catalyst a ruthenium complex bearing as a ligand certain optically active diphosphine compound and a readily synthesized amine compound. For example, aromatic ketones and heteroaromatic ketones are reacted with hydrogen and/or a hydrogen donating compound in the presence of the ruthenium complex.

Process for producing optically active secondary alcohol

The problem to be resolved by the present invention is to provide a method for efficiently synthesizing optically active lower aliphatic alcohols that have difficulty in separation from organic solvents, without using a special reactor. The present invention relates to a method for producing an optically active aliphatic alcohol having a fluorine atom at &#x3b1; position, wherein an optically active alcohol is produced by reacting an aliphatic ketone having a fluorine atom at &#x3b1; position in water using a formate, under the presence of an asymmetric catalyst represented by general formula (1) and an acid.

Process for producing optically active aliphatic fluoroalcohol

A novel ruthenium complex which is a highly efficient catalyst useful for the production of optically active 3-quinuclidinols, and a process for production of optically active 3-quinuclidinols using the ruthenium complex as a catalyst, where the optically active 3-quinuclidinols are useful as an optically active, physiologically active compound utilized in medicines and agrichemicals or as a synthetic intermediate such as a liquid crystal material.

Process for production of optically active quinuclidinols

The invention provides a method for producing optically active 3-quinuclidinols having one or more substituted groups at the 2-position; wherein 3-quinuclidinones having one or more substituted groups at the 2-position are reacted with compounds providing hydrogen in the presence of a certain metal complex.

Method for producing optically active quinuclidinols having one or more substituted groups at the 2-position

A sulfonate catalyst represented by the formula below and a ketone compound are placed in a solvent, and the ketone compound is hydrogenated by mixing in the presence of hydrogen to produce an optically active alcohol. 

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Saitama, Japan

Takeaki Katayama