Fujifilm Corporation

Toyama Chemical Co., Ltd.

Fujifilm Toyama Chemical Co., Ltd.

Takayuki Yamakawa

Daisuke Nakagawa

Tadashi Tanaka

Hidenobu Kuniyoshi

Tatsuya Murakami

Takehiro Yamane

Shinichiro Sekine

Shintaro Tanabe

Hirofumi Fukunaga

Issei Doi

Masataka Fujino

Hideyasu Fujiwara

Yoshitake Konishi

Daisuke Kubo

Yasuhiro Tsutsui

Eiichi Kodama

Sachiko Shinjo

An object of the present invention is to provide a compound useful as an anti-tumor agent or the like, as well as a pharmaceutical composition, an anti-tumor agent, and a dihydroorotate dehydrogenase inhibitor, each of which contains the compound. According to the present invention, a compound represented by General Formula (1) or a salt thereof is provided. In the formula, Rrepresents a hydrogen atom or a Calkyl group; R, R, R, and Rare the same as or different from each other and each represent a hydrogen atom, a halogen atom, a Calkyl group which may be substituted, a Calkoxy group which may be substituted, or the like; R's are the same as or different from each other and each represent a halogen atom, a Calkyl group which may be substituted, or a Calkoxy group which may be substituted; Rrepresents a Ccycloalkyl group which may be substituted, or the like; m represents an integer of 0 to 6; and a broken line represents a single bond or a double bond.

Pyrazine derivative or salt thereof, and use of same

An object of the present invention is to provide a compound exhibiting an excellent drug efficacy as an anti-adenoviral agent, and an anti-adenoviral agent. The present invention provides a compound represented by General Formula [1]

Cyclobutyl purine derivative or salt thereof

A novel amine derivative expressed by general formula (1) (in the formula: G, G, and Gare the same or different and represent CH or a nitrogen atom; Rrepresents a chlorine atom, an optionally-substituted Ccycloalkyl group, or the like; Rrepresents &#x2014;COOR(in the formula, Rrepresents a hydrogen atom or a carboxyl protective group), or the like; Rrepresents a hydrogen atom, or the like; and Rrepresents an optionally-substituted condensed bicyclic hydrocarbon group, an optionally-substituted bicyclic heterocyclic group, or the like), or a salt thereof is useful in procedures such as the treatment or prevention of conditions related to excessive keratinocyte proliferation.

Amine derivative or salt thereof

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Kaisei, Japan

Takayuki Yamakawa