Meiji Seika Kaisha, Ltd.

Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Takayuki Usui

Seiji Shibahara

Tomio Takeuchi

Shinichi Kondo

Takashi Tsuruoka

Kiyoaki Katano

Daishiro Ikeda

Shuichi Gomi

Atsushi Tamura

Tetsuya Matsushima

Toshiaki Kudo

Yukiko Hiraiwa

Masaharu Shiotani

Yoko Ikeda

Tetsutaro Niizato

Naoto Ohkura

Shigeki Suzuki

Yuuko Nakatani

Chidsuko Kuroda

Hamao Umezawa

Sumio Umezawa

Shigeharu Inouye

Tsutomu Tsuchiya

Kenichi Kurihara

Tsuneo Okonogi

Keiichi Ajito

Yuichi Yamamoto

Osamu Makabe

Tsutomu Tsuruoka

Susumu Nishimura

Osamu Itoh

Kozo Nagaoka

Tsuneo Ishizuka

Nobuko Okada

Tetsuro Hara

Nitrogen-containing heterocyclic compounds and therapeutic agents for hyperlipidemia comprising the same

Nitrogenous heterocyclic compounds and hyperlipemia remedy containing the same

As new dibekacin derivatives and new arbekacin derivatives are now provided 2'-amino-2'-deoxydibekacin, 2'-amino-5,2'-dideoxydibekacin, 2'-amino-2'-deoxyarbekacin, 2'-amino-5,2'-dideoxyarbekacin, 2'-amino-5,2'-dideoxy-5-epi-fluoroarbekacin and 2'-amino-5,2'-dideoxy-5-epi-aminoarbekacin which all exhibit high antibacterial activity against a wide variety of gram-positive and gram-negative bacteria, including resistant bacteria such as methicillin-resistant Staphylococcus aureus and which are of low toxicity to mammals and are useful as antibacterial agent for treatment of bacterial infections.

Dibekacin derivatives and arbekacin derivatives active against resistant

16-membered macrolide compounds wherein both of hydroxyl groups at the 3'- and 4'-positions form ether bonds together with two alkyl groups which are either the same or different from each other is useful as an antibacterial agent. The macrolide compounds represented by formula (I) are prepared by chemically modifying midecamycin A.sub.3 to obtain a synthesis intermediate of the formula (II), which is further chemically modified. ##STR1##

16-membered macrolide derivative having sustained antibacterial activity

A novel 2-piperidinecarboxylic acid derivative represented by the formula: ##STR1## wherein X represents an oxygen atom, a sulfur atom or a nitrogen atom to which a hydrogen atom is bound; and * represents that the configuration of the carbon atom binding to the carboxyl group is (S), (R) or a mixture of (S) and (R); and a pharmaceutically acceptable salt thereof which exerts an antitumor effect over a wide range of tumor cells.

2-piperidinecarboxylic acid derivative, oncogene suppressor and agent

A new semi-synthetic antibiotic, 3'-deoxystreptomycin is now provided, which is useful as an antibacterial agent and is produced from 3'-deoxydihydrostreptomycin by a process comprising oxidizing the 3'-hydroxymethyl group of 2,5,6,4',6'-penta-O-acetyl-2'-N-benzyloxycarbonyl-3'-deoxydihydrostreptomy cin as prepared by skilled introduction of amino-protecting group and hydroxyl-protecting group of appropriately selected natures into 3'-deoxydihydrostreptomycin, and then removing the protective groups from the oxidation product, 2,5,6,4',6'-penta-O-acetyl-2'-N-benzyloxycarbonyl-3'-deoxystreptomycin.

3'-Deoxystreptomycin production thereof and pharmaceutical compositions

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Kanagawa, Japan

Takayuki Usui