Otsuka Pharmaceutical Company, Limited

The Rockefeller University

Takayuki Shiratsuchi

Osamu Ogawa

Moriya Tsuji

Seiji Naito

Toyokazu Seki

Taiji Tsukamoto

Yoshihiko Hirao

Susumu Kagawa

Yoshiaki Nose

Tsuyoshi Nakamura

The present disclosure relates to adenovirus protein modifications to augment immune response to a transgene of a recombinant adenovirus and to circumvent pre-existing anti-adenovirus immunity. Some embodiments are directed to a recombinant adenovirus derived from a recombinant adenovirus plasmid vector, wherein the recombinant adenovirus plasmid vector comprises a nucleotide sequence encoding acircumsporozoite protein, or antigenic portion thereof, operably linked to a heterologous promoter and a modified capsid or core protein, wherein an immunogenic epitope ofcircumsporozoite is inserted into or replaces at least part of a capsid or core protein. Other embodiments are directed to a pharmaceutical composition or a malaria vaccine composition comprising a recombinant adenovirus according to the above embodiments. Further embodiments include a method of treating, preventing, or diagnosing malaria, comprising administering a therapeutic amount of the pharmaceutical composition or malaria vaccine composition in accordance with the above embodiment.

Modification of recombinant adenovirus with immunogenic plasmodium circumsporozoite protein epitopes

The present invention provides an identification marker responsive to IFN therapy for renal cell cancer and a means of detecting the same. Namely, a method which comprises preparing a genomic DNA of a human gene or a complementary strand thereof from a specimen of a patient with renal cell cancer, analyzing the DNA sequence of the genomic DNA or the complementary strand thereof to determine the gene polymorphism of the human gene, and evaluating the tumor-suppression effect of IFN therapy on renal cell cancer by using the polymorphism as an indicator.

Identification marker responsive to interferon therapy for renal cell cancer

Growing community of inventors

Tokushima, Japan

Takayuki Shiratsuchi