Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Sankyo Seisakusho Co. & Eisai Co., Ltd.

Sankyo Seisakusho Co.

Sankyo Seisakusho & Eisai Co., Ltd.

Takayuki Ohwaki

Yutaka Morita

Yuki Tsushima

Heizaburo Kato

Yasuo Miyake

Masaharu Nakajima

Shigeru Sakashita

Masanobu Yasui

Masahiro Kawahara

Takeshi Nakagawa

Akira Kato

Yasuharu Saeki

Hisao Furitsu

Aishin Shinoda

Takeshi Watanabe

The present invention provides a quickly disintegrating tablet which has quick disintegrability and solubility in an oral cavity, and does not have uncomfortable tastes such as bitterness, has a small variation of a tablet physical property even in storage under a humidifying condition, and has substantially no change in a medicine content in the tablet and tablet appearance and which is superior in stability; and a manufacturing method of the tablet. That is, it provides: a quickly disintegrating tablet which is prepared by blending a medicine with a saccharide and polyvinyl alcohol, which has small variations of tablet weight, tablet hardness, tablet diameter and tablet thickness, and which is superior in medicine stability in the tablet; and a manufacturing method of the tablet.

Rapidly disintegrating tablet containing polyvinyl alcohol

Rapidly disintegrable tablet containing polyvinyl alcohol

The present invention provides an intraoral quickly disintegrating tablet containing a phosphodiesterase inhibitor having an effect of improving the erectile dysfunction and a method for manufacturing the tablet. The present invention also provides an intraoral quickly disintegrating tablet containing a slightly soluble pharmaceutical agent having an improved solubility and a method for manufacturing the tablet. That is, it is an intraoral quickly disintegrating tablet containing a cyclic GMP phosphodiesterase inhibitor and a saccharide, and a method for manufacturing the tablet. Further, it is a method for manufacturing an intraoral quickly disintegrating tablet, which comprises dissolving a slightly soluble pharmaceutical agent in an organic solvent or an aqueous organic solvent together with a surfactant and/or a water-soluble polymer, coating the solution on a filler or granulating it with a filler to obtain molded products, mixing a saccharide with them, adding an organic solvent, water or an aqueous organic solvent thereto, followed by kneading, and subjecting it to a compression-molding.

Tablets immediately disintegrating in the oral cavity

A method and an apparatus for manufacturing tablets of moist powder which is produced by adding an additive agent such as an excipient or a binder to medical ingredients, further adding a solvent such as water, ethanol or the like, and kneading the mixture. The tablet manufacturing method comprises the steps of: preparing a first table and a second table which are intermittently rotated and driven relatively with respect to each other; supplying moist powder from a hopper into filling holes of the first table; filling the supplied moist powder into mold cavities of the second table under a pressurized condition by means of filling pins of a filling and pressurizing device at a location where the first table overlaps with the second table; relatively moving the first and second tables with respect to each other so as to level the surface of the moist powder in the mold cavities by removing the excessive powder; chamfering the surface of the moist powder by a finish-forming device; drying the moist powder by a dryer; and releasing the moist powder out of the mold cavities by a release device.

Apparatus for manufacturing tablets

Method for manufacturing tablets

It is an object of the present invention to realize a method and an apparatus for efficiently mass-producing tablets of high mechanical strength, accuracy and quality which are so excellent in solubility and collapsibility that they can be easily taken by persons of advanced ages and infants. By using a turn table and endless belt means to which a number of dies are connected, a part of which turn table contacts with the endless belt means, the turn table and the endless belt means being adapted to relatively move with respect to each other, receptacles are formed by pressing plastic polymer film in mold cavities of the dies. Moist powder supplied from a hopper into filling holes of the turn table is pressurizingly filled in the receptacles by means of a filling and pressurizing device in the region where the turn table is laid above the endless belt means. The surface of this pressurizingly-filled moist powder is leveled by removing the excessive powder when the endless belt means is relatively moved with respect to the turn table, thus forming a tablet. Then, the surface of the moist powder is chamfered, the mass of the moist powder is treated by a dryer, the receptacles are closed by a sealing unit, and they are cut by a predetermined number by a cutting device, thereby finishing tablet products.

Method and apparatus for manufacturing tablets

A composition containing ubidecarenone, a glycerol mono-fatty acid ester and/or a propylene glycol mono-fatty acid ester, and a liquid oil. Oral administration of the composition provides a promoted absorption of ubidecarenone which is used for improving a coronary function.

Composition containing ubidecarenone with absorption promoted

An inclusion compound composed of tripamide and cyclodextrin markedly improves the solubility of tripamide which is effective for treatment of essential hypertension.

Tripamide and cyclodextrin inclusion compound

This invention provides a process for sealing a body and a cap of a capsule which comprises successively dipping a gelatin hard capsule containing drugs one by one in a mixed solvent of water and ethanol whose volume ratio to water is 50-55%, thereafter taking said capsule out of this solvent and drying each capsule separately.

Process for sealing body and cap of gelatin hard capsule and apparatus

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Inuyama, Japan

Takayuki Ohwaki