Chugai Seiyaku Kabushiki Kaisha

Takayuki Kamikawa

Shojiro Kadono

Yuji Hori

Shun Shimizu

Mika Sakurai

Taro Miyazaki

Hiroki Kawauchi

Kanako Tatsumi

Masaki Kamimura

Masami Hasegawa

Yoshinori Narita

Akira Hayasaka

Naoka Hironiwa

Tomoyuki Igawa

Takeaki Kawai

Nasa Savory

Futa Mimoto

An objective of the present disclosure is to provide anti-CD137 antigen-binding molecules which have immunocyte-activating effect, cytotoxic activity, or anti-tumor activity, and meanwhile have reduced effect on non-tumor tissues such as normal tissues and produce less side effects, and methods of using the same. Anti-CD137 antigen-binding molecules which have immunocyte-activating effect, cytotoxic activity, or anti-tumor activity, and meanwhile have reduced effect on non-tumor tissues such as normal tissues and produce less side effects, are provided by discovering and producing CD137 antigen-binding molecules whose binding activity to CD137 depends on various substances (for example, small molecule compounds) in target tissues. Methods of using the same, pharmaceutical formulations, and such are also provided. The present disclosure also provides an antigen-binding molecule whose binding activity to an antigen varies depending on a small molecule compound, a preparation method thereof, and uses thereof.

Anti-CD137 antigen-binding molecule and utilization thereof

Growing community of inventors

Kanagawa, Japan

Takayuki Kamikawa