Carna Biosciences, Inc.

Sbi Biotech Co., Ltd.

Crystalgenomics, Inc.

Takayuki Irie

Masaaki Sawa

Tokiko Asami

Chika Tanaka

Yoko Funakoshi

Ayako Sawa

Takao Kiyoi

Wataru Kawahata

Seong Gu Ro

Takahiro Miyake

Shigeki Kashimoto

Yuko Asamitsu

Sayuri Ito

Choul Hong Park

An oxoisoquinoline compound of the following formula: or a pharmaceutically acceptable salt thereof; a pharmaceutical composition comprising the oxoisoquinoline compound or salt; and a method for treating B-cell lymphoma comprising administering the oxoisoquinoline compound or salt to a patient.

Oxoisoquinoline derivatives

To provide a novel furanone derivative, and a medicine including the same. The furanone derivative is represented by the formula (I): wherein A represents &#x2014;COOR1 or a hydrogen atom; R1 represents a hydrogen atom, an optionally substituted hydrocarbon group, or an optionally substituted heterocycle; R2 and R3 are the same or different and each independently represent a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted phenyl group, an optionally substituted heterocycle, an optionally substituted heterocyclic fused ring, or an optionally substituted amino group; or alternatively, R2 and R3, taken together with the nitrogen atom to which they are attached, may form an optionally substituted heterocycle or an optionally substituted heterocyclic fused ring; and R4 represents a hydrogen atom or a halogen atom; with the proviso that when A represents &#x2014;COOR1, R2 and R3 are not optionally substituted amino groups at the same time, and when A represents a hydrogen atom, R3 represents a hydrogen atom.

Furanone derivative

The purpose of the present invention is to provide a novel triazine derivative of the formula (I): wherein

Triazine derivative

An object of the present invention is to provide thiazolidinone derivatives. More specifically, an object of the present invention is to provide novel compounds having a CDC7 inhibitory action. The present invention provides thiazolidinone derivatives represented by the formula (I)  The compounds of the present invention inhibit the CDC7 protein kinase activity, and suppress cell proliferation.

Thiazolidinone derivative

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Kobe, Japan

Takayuki Irie