Astellas Pharma Gmbh

Hitachi Zosen Corporation

Nagaoka Corporation

R-tech Ueno, Ltd.

Takayuki Inoue

Ryuji Ueno

Masataka Morita

Takashi Tojo

Akira Tanaka

Mitsuru Ohkubo

Shohei Shirakami

Koichiro Mukoyoshi

Masaki Inui

Hiroshi Sasaki

Yutaka Nakajima

Kousei Yoshihara

Yasuyuki Higashi

Fumie Takahashi

Keiko Hatanaka

Akira Nagashima

Hisao Hamaguchi

Shigeki Kunikawa

Takeshi Hondo

Hideyuki Niizato

Hitoshi Mimura

Kazuo Nakai

Kiyokazu Mukai

Hitoshi Sawada

Akira Okimoto

Kousel Yoshihara

In this infiltration intake system, a structural body integrally includes a waster discharge direction control portion controlling a discharge direction for wastewater discharged from a filter toward a raw water side at a backwash time with a backwash mechanism portion in a prescribed wastewater discharge direction.

Infiltration intake system

This infiltration intake system for a revetment wall includes a structural body, set on an outer wall surface of a revetment wall, including a filter storage portion, a filter stored in the filter storage portion of the structural body, and a water guide portion guiding treated water passing through the filter toward the side of an inner wall surface of the revetment wall.

Infiltration intake system for revetment wall

To provide a cleaning apparatus suitable for removing clogging substances trapped in a surface layer of a sand filtration layer. A cleaning apparatus equipped with drive wheels serving as a driving device configured to move across a surface of a sand filtration layer. A pump and a jet nozzle are provided as an agitation device configured to agitate a surface layer portion of the sand filtration layer only at a desired depth, and which blows the clogging substances upward into the seawater in a turbid water intake pit together with a filtration sand. A perforated pipe for suctioning turbid water, a pump, an ejector, and a discharge pipe for dilute turbid water are provided as a suction and discharge device configured to suction turbid water blown upward into seawater in the water intake pit by the agitation device, and discharge it to outside of the turbid water intake pit. Prevents clogging by performing a timely cleaning of the sand filtration layer, thereby making it possible to maintain a high-speed seawater infiltration rate for seawater. Impact on the surrounding environment is reduced, because the apparatus suctions turbid water containing clogging substances which is blown upward into the turbid water intake pit, and discharges it to outside of the system.

Cleaning apparatus for filtration layer in seawater infiltration intake

The invention relates to compound of the formula (I) or its salt, wherein &#x2014;R, &#x2014;R, &#x2014;R, &#x2014;R, &#x2014;R, -M-, &#x2014;X&#x2014; and &#x2014;Y&#x2550; are as defined in the description, their use of as, medicament, the process for their preparation and use for the treatment of JAK3 mediated diseases. 

Heterocyclic Janus Kinase 3 inhibitors

The present invention provides a compound of formula (I) having an excellent JAK3 inhibition activity and being useful as an active ingredient of an agent for treating and/or preventing various immune diseases including autoimmune diseases inflammatory diseases, and allergic diseases. The compound according to the present invention has an inhibition activity against JAK3 and is thus useful as an active ingredient of an agent for treating or preventing diseases caused by undesirable cytokine signal transmission (e.g., rejection during organ/tissue transplantation, autoimmune diseases, multiple sclerosis, rheumatoid arthritis, psoriasis, asthma, atopic dermatitis, Alzheimer's disease, and atherosclerotic disease), or diseases caused by abnormal cytokine signal transmission (e.g., cancer and leukemia). 

Heterocyclic janus kinase 3 inhibitors

A compound of the formula (I): R&#x2014;NH&#x2014;X&#x2014;Y-Z (I) wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof useful as a vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, a method for preventing or treating a VAP-1 associated disease, especially macular edema, which method includes administering an effective amount of the compound or a pharmaceutically acceptable salt thereof to a mammal, and the like.

Thiazole derivatives

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Osaka, Japan

Takayuki Inoue