Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Takayuki Hida

Shigeki Hibi

Hiroyuki Yoshimura

Mitsuo Nagai

Kouichi Kikuchi

Katsuya Tagami

Shinya Abe

Seiko Higashi

Seiichi Kobayashi

Kenji Tai

Makoto Okita

Norimasa Miyamoto

Naoki Tokuhara

Ieharu Hishinuma

Junichi Nagakawa

Makoto Asada

Aichi Ogasawara

Takashi Yamanaka

Yasushi Okamoto

Takashi Sato

Naoki Kobayashi

Yumiko Nagasaka

Hisashi Shibata

Kokichi Harada

Isao Yamatsu

Shuhei Miyazawa

Yoshinori Takahashi

Yoshihiko Kotake

Osamu Asano

Motohiro Soejima

Yorihisa Hoshino

Koichi Kikuchi

Takeshi Nagasu

Hitoshi Harada

Nozomu Koyanagi

Hiroshi Yoshino

Kentaro Yoshimatsu

Kogyoku Shin

Tatsuya Yoshiuchi

Yoichi Ozawa

Takashi Owa

Nobuyuki Yasuda

Mitsuhiro Ino

Naoko Hata

Tetsuya Hirakawa

Mutsuko Tabata

Kyosuke Kito

Masahiro Yasuda

Michiko Kosasa

Tatsuo Okauchi

Tomoko Sekiya

Toru Sawai

Eiki Takahashi

Takashi Seiki

Tohru Arai

Relaxin-3 is found to have feeding-stimulating activity, body weight increasing activity, and fat weight increasing activity when intracerebroventricularly administered to rats through observation of amount of feeding, body weight and fat weight after administration of relaxin-3. This invention includes: a polypeptide having useful effects in stimulating feeding, increasing body weight, and fattening; a therapeutic agent containing the polypeptide; a method of screening for a compound, a substance, or a salt thereof which activates or suppresses a receptor of the polypeptide; a kit for screening; and an agent with a substance which inhibits expression of the polypeptide, such as a feeding-suppressing agent, a therapeutic agent for the treatment of obesity, and a therapeutic agent for the treatment of diabetes.

Methods of affecting feeding and weight in mammals by administration of relaxin-3

The present invention provides a medicament having a gentle but strong defecation-promoting action without causing diarrhea. That is, it provides a defecation-promoting agent comprising a compound having an adenosine Areceptor antagonism, preferably an adenosine Areceptor antagonism, or a salt thereof.

Medicinal compositions promoting bowel movement

An appetite-stimulating agent and a therapeutic agent for anorexia, each comprising, as an active ingredient, a sulfonamide derivative or sulfonic acid ester derivative represented by the following general formula (I):

Appetite-stimulating agents and remedies for anorexia

The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrates thereof,wherein Ris a hydrogen atom, etc.; Ris a hydrogen atom, etc.; M' represents a hydrogen atom, a halogen atom or a Calkyl group; R&#x2032; represents a hydrogen atom or a Calkyl group; and W&#x2032; represents a phenyl group, pyridyl group, thienyl group, or furyl group, each being optionally substituted; and a pharmacologically acceptable salt thereof or hydrates thereof.

Tricyclic fused heterocyclic compound, process for preparing it and medicament comprising it

Heterocycle-containing carboxylic acid derivative and drug containing the same

Mono- or polyenic carboxylic acid derivatives

Carboxylic acid derivatives having fused rings

Described is a heterocycle-containing carboxylic acid derivative represented by the following formula (I):

To provide novel compounds relating to retinoid which can substitute for retinoic acid used for preventing and treating several diseases and having antagonism against retinoid. Heterocyclic compounds represented by the general formula (1-I) or physiologically acceptable salts thereof:

Fused-ring carboxylic acid derivatives

The present invention provides a medicament exhibiting excellent retinoic acid receptor agonism. A Carboxylic acid derivative having a fused ring which is represented by the following formula or a pharmacologically acceptable salt thereof: ##STR1## {wherein the symbol ##STR2## represents a single bond or a double bond; X, Y, Z, P, Q, U, V and W are each a group represented by the formula: --O-- or --S--, or a group represented by the formula: ##STR3## [wherein R.sup.k (k: 1 to 8) is hydrogen, halogeno, optionally substituted lower alkyl or the like, with either of R.sup.7 and R.sup.8 being a group represented by the formula: ##STR4## (wherein A and B are each independently an optionally substituted aromatic hydrocarbon ring or an optionally substituted unsaturated heterocycle; and D is optionally protected carboxyl)]}.

Compounds of the formula and compounds of the formula ##STR1## or their salts have the potent ability to bind to retinoic acid receptors thus useful in treating psoriasis and rheumatoid arthritis.

Heterocycle-containing carboxylic acid derivative and drug containing

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Tsukuba, Japan

Takayuki Hida