Ajinomoto Co., Ltd.

Fujitsu Corporation

Takayuki Hamada

Kunisuke Izawa

Takayuki Suzuki

Masanobu Yatagai

Hiroyuki Nohira

Sanroku Tsukamoto

Ryoji Noyori

Takao Ikariya

Tomoyuki Onishi

Takayoshi Torii

Masayuki Oshita

Kunisuki Izawa

Hiroki Oshiyama

An interpolation circuit includes: a plurality of holding circuits configured to each hold a corresponding input data input chronologically; and a generating circuit configured to generate interpolation data by giving weights, based on an interpolation code, to input data that are chronologically adjacent to each other and are held by the plurality of holding circuits and combining the weighted data together.

Interpolation circuit and receiving circuit

An electronic circuit includes: a weighting circuit configured to generate a first current by weighting and combining a first input signal and a second input signal in accordance with a modifiable coefficient and to generate a second current by weighting and combining a first inverted signal and a second inverted signal in accordance with the coefficient, the first inverted signal being an inverted signal of the first input signal, the second inverted signal being an inverted signal of the second input signal; and a decision circuit configured to decide on an output signal by comparing the first current with the second current.

Electronic circuit

In a phase adjustment circuit, a first phase adjuster has a plurality of parallel-connected first inverters that receives an input signal to be phase-adjusted, wherein a first inverter to be activated is selected by a first control signal. A second phase adjuster has a plurality of parallel-connected second inverters that receives the input signal with a predetermined delay time, wherein a second inverter to be activated is selected by a second control signal. An output circuit receives output signals of the first and second phase adjusters and outputs a signal whose phase is adjusted within a range of the delay time. The second phase adjuster further includes transistors connected to the second inverters. During the delay time, these transistors block a current path between the first and second phase adjusters, under the control of the input signal.

Phase adjustment circuit and interface circuit

The present invention provides a production method including reacting a diphenylmethylene halide compound represented by the following formula (1) with a malonic acid diester compound represented by the following formula (2) in an organic solvent selected from N-methyl-2-pyrrolidone, N-ethyl-2-pyrrolidone and N,N-dimethylformamide, in the presence of a base selected from an alkali metal hydride and an alkali metal t-butoxide to give a diester compound represented by the following formula (3), and then subjecting the diester compound to hydrolysis and decarboxylation to give a diphenylalanine compound represented by the following formula (4). According to the present invention, diphenylalanine compound (4) can be obtained industrially advantageously in a high yield. wherein each symbol is as defined in the specification.

Production method of optically active diphenylalanine compounds

Optically active diphenylalanine compounds may be conveniently prepared in a good yield by reacting a diphenylalanine compound represented by formula (1) with an optically active amine compound represented by formula (2) in the presence of an organic solvent to give a diastereomeric salt represented by formula (5) and then treating the diastereomeric salt under acidic conditions to give an optically active diphenylalanine compound represented by formula (3): wherein each symbol is as defined in the specification.

Production method of optically active dephenylalanine compounds

The present invention relates to a method of producing a compound represented by the formula [I] or a salt thereof, which comprises reacting a compound represented by the formula [II] or a salt thereof with a compound represented by the formula [III] or a salt thereof, in the presence of a base, in alcohol, and provides a production method of an O-substituted tyrosine compound, which is superior in productivity, versatility and safety, and economically and industrially useful: wherein each symbol is as defined in the specification.

Production method of O-substituted tyrosine compound

The present invention provides an effective method for the production of optically active N-aryl-&#x3b2;-amino acid compounds, which at the same time is suitable for industrial production. In the method of the present invention optically active sulfonylated &#x3b2;-hydroxycarboxylic acid compounds, which are readily derived from &#x3b2;-keto carboxylic acid compounds, are reacted with aromatic amines to produce optically active N-aryl-&#x3b2;-amino acid compounds.

Production method for optically active N-aryl-&#x3b2;-amino acid compounds

A process of preparing an optically active halohydrin compound characterized by comprising asymmetric hydrogen transfer reduction of an &#x3b1;-haloketone compound in the presence of a group 9 transition metal compound having a substituted or unsubstituted cyclopentadienyl group and an optically active diamine compound. The asymmetric hydrogen transfer reduction is preferably conducted in the presence of a base.

Process for producing optically active halohydrin compound

Optically active N-(S-2-acetylthiomethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester useful as an enkephalin inhibitory agent or ACE inhibitory agent can be produced at low cost in an industrial manner, by a method comprising subjecting optically active 2-hydroxymethyl-3-phenylpropionic acid and glycine benzyl ester to condensation to subsequently convert the hydroxyl group into an elimination group, and substituting the elimination group with an acetylthio group.

Method for producing optically active phenylpropionic acid derivative

A process for producing a 2-aralkyl-3-hydroxypropionic acid (or its ester), comprising the steps of: reacting a 3-hydroxy-2-methylene-3-arylpropionic acid ester, easily obtained by the reaction of an arylaldehyde with an acrylic acid ester, with an acid anhydride to form a 2-aralkylidene-3-acyloxypropionic acid ester; subjecting the same to hydrolysis or alcoholysis; and reducing the resulting 2-aralkylidene-3-hydroxypropionic acid or its ester. The reduction step may be conducted in the presence of a base.

Process for producing propionic acid derivatives

A process for preparing optically active 2-hydroxymethyl-3-phenylpropionic acid by resolving (RS)-2-hydroxymethyl-3-phenylpropionic acid via crystallization of an optically active amine salt, where the amine is optically active cis-1-amino-2-indanol salt, optically active .alpha.-methylbenzylamine salt, or optically active 3-methyl-2-phenyl-1-butylamine salt.

Process for preparing optically active

A compound selected from the group consisting of

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Kawasaki, Japan

Takayuki Hamada