Tohoku University

Takayuki Doi

Hiroaki Shimokawa

Kimio Satoh

Ryo Kurosawa

Jyunken Aoki

Kuniyuki Kano

Yoshiharu Iwabuchi

Yoshiteru Oshima

Haruhisa Kikuchi

Hidetoshi Tokuyama

Akira Sugawara

Hirofumi Ueda

Atsushi Yokoyama

Susumu Suzuki

The present invention provides a compound represented by chemical formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same.

1, 3-dioxolane derivative

The present invention provides a preventive or therapeutic agent for pulmonary hypertension, including a compound represented by the following formula (I) or a salt thereof: where: &#x2014;A&#x2014; represents &#x2014;NH&#x2014;, &#x2014;S&#x2014;, or &#x2014;O&#x2014;; Rand Rare identical to or different from each other, and each represent a hydrogen atom or an alkyl group; Rrepresents a hydrogen atom, a halogen atom, or an alkyl group; Rrepresents a hydrogen atom or an alkyl group; Rrepresents a hydrogen atom or an alkyl group; Rand Rare identical to or different each other, and each represent a hydrogen atom, a halogen atom, or an alkyl group; and Rand Rmay form an unsaturated hydrocarbon six-membered ring together with a carbon atom to which Ris bonded and a carbon atom to which Ris bonded.

Prophylactic or therapeutic agent for pulmonary hypertension comprising unsaturated 5-membered heterocycle-containing compound

A problem to be solved by the present invention is to provide a novel preventive or therapeutic agent for pulmonary hypertension containing as an active ingredient a compound that has not been known for a therapeutic effect on pulmonary hypertension heretofore. The present invention provides a preventive or therapeutic agent for pulmonary hypertension containing emetine or a salt thereof.

Pulmonary hypertension preventative or therapeutic agent containing crude drug

Growing community of inventors

Miyagi, Japan

Takayuki Doi