Takeda Chemical Industries, Inc.

Takeda Pharmaceutical Company Limited

Takayuki Doen

Naoki Asakawa

Shigeyuki Takada

Yutaka Yamagata

Nobuyuki Takechi

Masao Nagao

An injectable composition comprises a benzimidazole compound having an antiulcer action and a strong alkali (e.g., an alkali metal hydroxide such as sodium hydroxide) in a proportion of about 1 equivalent of the latter relative to 1 mol of the former, and is substantially free from a nonaqueous solvent. The injectable composition may comprise N-methylglucamine, and a saccharide (such as mannitol). The injectable composition may be a freeze-dried preparation. The freeze-dried preparation is dissolvable in or dilutive with a distilled water for injection or an infusion solution without a nonaqueous solvent. The injectable composition is useful as an antiulcer agent.

Injections

A process for conveniently producing a stable protein powder retaining the higher-order structure at a high level which comprises freezing a protein-containing solution at a cooling rate of about &minus;300 to &minus;10&deg; C./min. and then drying.

Proces for producing protein powder

Growing community of inventors

Suita, Japan

Takayuki Doen