Riken Corporation

Ozeki Corporation

Alfresa Pharma Corproation

Takayuki Bogaki

Toshitaka Minetoki

Nobuyoshi Esaki

Tohru Yoshimura

Yosky Kataoka

Naoto Matsuyama

Koji Mizuno

Kenji Ozeki

Masanori Yamato

Yasuhisa Tamura

Satoshi Kume

Kazuhisa Hizume

Satoshi Okazaki

Miyo Hirata

Shinya Okuda

Hiroyuki Yamada

Haruka Kado

The present invention provides a novel IL-1&#x3b2; and/or IL-6 expression inhibitor and use thereof. The IL-1&#x3b2; and/or IL-6 expression inhibitor in accordance with an aspect of the present invention contains a component derived from alcoholic fermentation lees.

Method for alleviating fatigue

A method for detecting or measuring homocysteine in a sample includes the steps of (a) reacting a D-amino acid present in a sample with a D-amino acid converting enzyme to convert the D-amino acid into a substance that does not serve as a substrate of D-amino acid oxidase or D-amino acid acetyltransferase; (b) reducing homocysteine in the sample with a thiol compound; (c) reacting the reduced homocysteine with a methyltransferase and a methyl donor to newly produce D-amino acid; and (d) reacting the produced D-amino acid with the D-amino acid oxidase or the D-amino acid acetyltransferase in the presence of an SH reagent to produce hydrogen peroxide, and color-developing the produced hydrogen peroxide by using an oxidative color-developing agent.

Method of measuring homocysteine

Growing community of inventors

Hyogo, Japan

Takayuki Bogaki