Tokyo Medical and Dental University

Tokai National Higher Education and Research System

Takayoshi Suganami

Akira Matsumoto

Yuji Miyahara

Hiroko Matsumoto

Miyako Tanaka

Yuki Morooka

A sugar-responsive gel that is highly resistant to temperature changes, and a sugar-responsive drug delivery device including such a gel. The sugar-responsive gel, which comprises a gel composition including a monomer having a hydroxyl group in addition to a phenylboronic-acid-based monomer, can exhibit suitable temperature resistance. A sugar-responsive drug delivery device including such a sugar-responsive gel is less susceptible to the effects of temperature changes, and therefore can prevent undesirable excessive delivery of a drug such as insulin.

Temperature-resistant sugar-responsive gel

An improved device capable of releasing a drug in response to stimuli such as a glucose concentration is provided. Provided is a drug delivery device, including a porous body such as a hollow fiber having biocompatibility and drug permeability, a stimuli-responsive gel composition filling inside of the porous body, and a drug surrounded by the gel composition inside of the porous body.

Drug delivery device

Growing community of inventors

Nagoya, Japan

Takayoshi Suganami