Fujisawa Pharmaceutical Company, Ltd.

Takayoshi Kinoshita

Kiyoshi Tsuji

Katsuya Nakamura

Tadashi Terasaka

Nobuo Seki

Isao Nakanishi

Hiroyuki Okumura

Susumu Tsujimoto

Masako Kuno

Nobuya Nishio

Akihiro Sato

Heterocyclic compound, composition and method for inhibiting adenosine deaminase

Imidazole compounds having adenosine deaminase inhibitory activity represented by formula (I) wherein R is hydrogen, hydroxy, protected hydroxy, or aryl optionally substituted with suitable substituent(s); R is hydrogen or lower alkyl; R is hydroxy or protected hydroxy; R is cyano, (hydroxy)iminoamino(lower)alkyl, carboxy, protected carboxy, heterocyclic group optionally substituted with amino, or carbamoyl optionally substituted with suitable substituent(s); and &mdash;A&mdash; is &mdash;Q&mdash; or &mdash;O&mdash;Q&mdash;, wherein Q is single bond or lower alkylene, provided that when R is lower alkyl, then R is hydroxy, protected hydroxy, or aryl optionally substituted with suitable substituent(s), its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective.

Imidazole compounds

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Tsukuba, Japan

Takayoshi Kinoshita