Ishihara Sangyo Kaisha, Ltd.

Takayoshi Ando

Hiroshi Yoshizawa

Tadashi Nakamura

Takeshi Ohshima

Norio Adachi

Shigeo Murai

Akihiko Isogai

Katsuyoshi Murakami

Shigeyuki Nishimura

Takao Awazu

Tatsuo Isogai

Hisayoshi Jonishi

Koji Hayashi

Isamu Katsuyama

Hayato Ariyoshi

Ryoji Koto

Akihiro Isogai

Sho Tokumoto

Masaru Kimura

Masahiko Sawaki

A method for separating and purifying 2-chloro-3-trifluoromethylpyridine useful as an intermediate for medicines, agrochemicals, and the like is provided. The method includes:

Method for separating and purifying 2-chloro-3-trifluoromethylpyridine

To provide a method for producing pyrimidine compound useful as an intermediate for agricultural chemicals or pharmaceuticals, which is simple in operation, presents high yield and produces only a small amount of by-products. The method comprises reacting a compound represented by the formula (I) with a compound represented by the formula (II) in the presence of a pyridine compound to produce a compound represented by the formula (III), a compound represented by the formula (IV) or their mixture. 

Method for producing pyrimidine compound

A method for producing 3-methyl-2-thiophenecarboxylic acid is provided. A method for producing 3-methyl-2-thiophenecarboxylic acid, which comprises reacting a compound represented by the formula (I): (wherein X is a chlorine atom or a bromine atom) with magnesium in the presence of an alkyl halide to give a Grignard reagent represented by the formula (II): (wherein X is the same as defined above), reacting the Grignard reagent of the formula (II) with carbon dioxide, and acidifying the reaction product.

Method for producing 3-methyl-2-thiophenecarboxylic acid

Because fluazinam is excellent as an active ingredient of pesticides and highly useful, it is desired to produce it efficiently in a proper form with simple operations at low cost in an environmentally friendly manner. The desired product is obtained in good yields with simple operations by using industrially advantageous reaction systems by a process comprising (1) a step of reacting ACTF and DCDNBTF in the presence of an alkali component, a solvent selected from the group consisting of ketones, nitriles, ethers and esters and a sufficient amount of water to substantially dissolve the alkali component, (2) a step of neutralizing or acidifying the reaction mixture with an acid and (3) a step of removing the solvent by distillation from the mixture containing fluazinam as the reaction product and the reaction solvent to precipitate crystals the product.

Process for producing toluidine compound

A process for producing 2-phenylacetophenone derivatives represented by the formula (I):(wherein X is an alkyl group or a haloalkyl group, and Y is a hydrogen atom, a halogen atom or an alkyl group which may be substituted), which comprises reacting a compound represented by the formula (II):(wherein X and Y are as defined above, and R is a hydrogen atom or an alkyl group) with an acid.

Process for producing 2-phenylacetophenone derivatives and precursors therefor

A method for producing 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine, which comprises reacting 3-hydroxy-3-mercaptomethylquinuclidine or a salt thereof and a carbonyl compound in the presence of a catalyst made of at least one member selected from the group consisting of tin halides, oxyacids of phosphorus, phosphorus oxyhalides and organic sulfonic acids, to produce cis-form 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine or a salt thereof.

Method for producing 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine

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Yokkaichi, Japan

Takayoshi Ando