Sanwa Kagaku Kenkyusho Co., Ltd.

Takayo Murase

Takuji Kakigami

Mitsuru Oka

Masahiro Shirai

Yuji Hayashi

Masahiro Yoshida

Mitsuaki Takeuchi

Motohiro Takeda

Mitsuhiro Makino

Masao Sakairi

Noriyasu Katoh

Toru Murase

A dipeptidyl peptidase IV inhibitor which is satisfactory in respect of activity, stability and safety and has an excellent action as a pharmaceutical agent. A compound represented by the following general formula or a pharmaceutically acceptable salt thereof: wherein Rand Reach represents hydrogen, an optionally substituted C1-6 alkyl group, or &#x2014;COORwhereupon Rrepresents hydrogen or an optionally substituted C1-6 alkyl group, or R, R, and a carbon atom together represent a 3- to 6-membered cycloalkyl group, Rrepresents hydrogen or an optionally substituted C6-10 aryl group, Rrepresents a hydrogen or a cyano group, D represents &#x2014;CONR-, &#x2014;CO&#x2014; or &#x2014;NRCO&#x2014;, Rrepresents hydrogen or an optionally substituted C1-6 alkyl group, E represents &#x2014;(CH)&#x2014; whereupon m is 1 to 3, &#x2014;CHOCH&#x2014;, or &#x2014;SCH&#x2014;, n is 0 to 3, and A represents an optionally substituted bicyclic heterocyclic group or bicyclic hydrocarbon group.

Compound inhibiting dipeptidyl peptidase IV

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Nagoya, Japan

Takayo Murase