Takeda Chemical Industries, Inc.

Takatsuka Yashiki

Hiroaki Okada

Yasuaki Ogawa

Shin-Ichiro Hirai

Yoshinobu Yoshimura

Yoshiaki Uda

Naoru Hamaguchi

Iwao Yamazaki

Yoko Nishida

A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not lower than about 5000 centiposes and finally subjecting the resulting emulsion to in water drying gives prolonged release of water-soluble drug.

Method for producing microcapsule

Prolonged release microcapsule

Prolonged release microcapsule of a water-soluble drug

Prolonged release microcapsules

Prolonged release microcapsules and their production

A pharmaceutical composition containing a hydrophilic drug which is poorly absorbable through the gastrointestinal tract, and cyclodextrin, increases the absorbability of the drug into the mammalian body when administered by a non-oral or non-injection route.

Pharmaceutical composition and its rectal use

Pharmaceutical composition and its nasal or vaginal use

Prolonged release microcapsule and its production

A novel steroid compound of the formula ##STR1## wherein A is a lower alkylene group; ##STR2## is an acyl group; and  is a single bond or a double bond, and methods of producing the compound (I) as follows: ##STR3## and a pharmaceutical composition containing the compound (I). The compound (I) exhibits excellent antiandrogenic activity on oral administration and can be used for the treatment of prostatic hypertrophy.

Double ester of 16.beta.-ethylestran-17.beta.-ol derivatives

A non-parenteral pharmaceutical preparation containing TRH, its salt, or its analogue is produced by employing the drug and a hydroxycarboxylic acid or polycarboxylic acid of 2 to 8 carbon atoms, and having the pH of the preparation adjusted to 2 to 6.

Pharmaceutical preparations containing TRH or its analogue

Cephalosporin derivatives of the formula: ##STR1## wherein R.sub.1 is methyl or ethyl and R.sub.2 is a straight-chain or branched alkyl group of 5 to 7 carbon atoms, and their pharmaceutically acceptable salts, which are effective as orally administrable antibiotic agents against both gram-positive- and negative-bacteria, and the production and compositions thereof, are proposed.

Cephalosporin derivatives

A preparation containing, as the main pharmaceutically active ingredient, a peptide having a luteinizing hormone-releasing hormone activity, is improved in its absorption by adding thereto a water-soluble aliphatic carboxylic acid of 2 to 6 carbon atoms.

Growing community of inventors

Hyogo, Japan

Takatsuka Yashiki