Kanegafuchi Kagaku Kogyo Kabushiki Kaisha

Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Takashi Yamashita

Tomio Takeuchi

Masa Hamada

Hiroshi Naganawa

Masaaki Ishizuka

Kenji Maeda

Kunio Isshiki

Hironobu Iinuma

A new antibiotic, named Conagenin, is provided which can exhibit useful carcinostatic or antitumor activities on carcinomas and tumors, particularly malignant tumors, of mammalian animals including man. Conagenin can be produced by fermentation of microorganisms of genus Streptomyces, typically Streptomyces roseosporus MI696-AF3 strain identified under the deposit number FERM BP-2738. Conagenin has formula (I) and is useful for medicinal purposes, particularly as carcinostatic agent or antitumor agent for inhibiting carcinomas and malignant tumors of mammalian animals, including man.

Carcinostatic or antitumor antibiotic, conagenin, and production and

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Numazu, Japan

Takashi Yamashita