Japan Tobacco Inc.

Leo-pharma A/s

Takashi Watanabe

Takashi Inaba

Soren Ebdrup

Tsubasa Takeichi

Akinobu Higashi

Hiromu Takiguchi

Kim Lebek Jensen

Per Vedsoe

Jan Bornholdt

Takuya Matsuo

Shinji Yata

Yoshikazu Hori

Takayuki Yamasaki

Yoshihisa Koga

Wataru Kondo

Taiichi Mine

Hidekazu Ozeki

The present invention provides processes for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives, which are useful as a Janus kinase (JAK) inhibitor, intermediates thereof, and processes for preparing the intermediates. The present invention provides processes for preparing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile using salts of (3S,4R)-1-benzyl-3-methyl-1,6-diazaspiro[3.4]octane with organic acids.

Process for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives and synthetic intermediates thereof

To provide a compound having an excellent inhibitory effect on vanilloid receptor subtype 1 (VR1) activity which is effective in treating diseases to which the vanilloid receptor subtype 1 (VR1) activity is involved, such as pain, acute pain, chronic pain, neuropathic pain, rheumatoid arthritis pain, neuralgia, etc. and a pharmaceutical composition containing the compound. The object has been attained by a condensed benzamide compound represented by the following formula (the symbols in the formula have the same meanings defined in the specification) or its salt: 

Condensed benzamide compounds and inhibitors of vanilloid receptor subtype 1 (VR1) activity

Method of and apparatus for storing tobacco or the like in high stacks and discharging the same, in which tobacco is charged into and stored in a plurality of vertically elongated storage chambers arranged side by side. The tobacco is discharged to fall onto a discharging conveyor arranged horizontally beneath the storage chambers, while changing the orientation of the tobacco layer from a horizontal to a vertical direction. The tobacco layer oriented in a vertical direction is transported by the discharging conveyor. Completion of the discharge is detected and then discharging the tobacco of the next chamber is started. Separating doffers are provided for cooperation with the discharging conveyor.

Method of and apparatus for storing tobacco or the like in high stacks

Growing community of inventors

Takatsuki, Japan

Takashi Watanabe