Meiji Seika Kaisha, Ltd.

Meiji Seika Kabushiki Kaisha

Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Maiji Seika Kaisha Ltd.

Meiji Saika Kaisha, Ltd.

Meuji Seika Kaisha Ltd.

Meiji Selka Kaisha, Ltd.

Neiji Seika Kaisha, Ltd.

Meiji Seika Kaburhiki Kaisha

Takashi Tsuruoka

Shigeharu Inouye

Taro Niida

Kiyoaki Katano

Tetsuro Watanabe

Hiroko Ogino

Tetsuo Takematsu

Makoto Konnai

Kunitaka Tachibana

Katsuyoshi Iwamatsu

Shinichi Kondo

Seiji Shibahara

Takashi Shomura

Shigeharu Inoue

Fumiya Hirano

Tomoya Machinami

Takemi Koeda

Fukio Konno

Shoji Omoto

Uichi Shibata

Yasukatsu Yuda

Satoru Nakabayashi

Fumio Kai

Yasuharu Sekizawa

Mami Kawaguchi

Hiroyasu Asaoka

Tamako Tomomoto

Motohiro Nishio

Masao Koyama

Masaji Sezaki

Eiki Shitara

Mitsugu Hachisu

Michio Kojima

Kazunori Ohba

Tetsutaro Niizato

Harumi Fukuyasu

Keinosuke Miyauchi

Hiroshi Watanabe

Takashi Yoshida

Yasuo Ohtsuka

Tetsuya Matsushima

Eiichi Akita

Tomoaki Miura

Haruo Yamamoto

Norio Ezaki

Takashi Shishikura

Yasuaki Ogawa

Kenichi Fushihara

Shokichi Ohuchi

Takayuki Usui

Naoto Ohkura

Yukiko Hiraiwa

Masaharu Shiotani

Seiji Tsutsumi

Kuniomi Matsumoto

Tsutomu Tsuruoka

Yuzo Kazuno

Shigeki Suzuki

Yuuko Nakatani

Shigeharu Inoye

Osamu Itoh

Hiroyuki Iida

Koji Tsuchiya

Takako Iwasaki

Masaro Shimizu

Keiko Shito

Kazue Yaegashi

Midori Ishikawa

Megumi Imai

Yasuko Isomura

Kenji Asai

Emiko Hatsushiba

Shigeru Hoshiko

Toyoaki Kawasaki

Naoki Yamazaki

Junko Tanaka

Akira Suzuki

Hitoshi Ikeda

Shunzo Fukatsu

Kunio Atsumi

Yasushi Murai

Shigeo Seki

Tsuneo Okonogi

Yujiro Yamada

Ken Nishihata

Katsuharu Iinuma

Tomizo Niwa

Kenji Sakagami

Takashi Hisamatsu

Naomi Osada

Shokichi Nakajima

Yasumitsu Kondo

Chuhei Nojiri

Osamu Makabe

Yasuyuki Ichimaru

Shinji Miyado

Shoichi Amano

Jiro Itoh

Yuji Matsuhashi

Nitrogen-containing heterocyclic compounds and therapeutic agents for hyperlipidemia comprising the same

Nitrogenous heterocyclic compounds and hyperlipemia remedy containing the same

Compounds of formulae (II), (III), (IV) and (V) or salts thereof are intermediates for pharmacologically active tricyclic benzazepine and benzothiazepine derivatives, ##STR1## wherein R represents hydrogen, alkyl, phenylalkyl, or a protective group of a triazole ring, R.sup.1 -R.sup.5 represent hydrogen, alkyl, alkenyl, alkoxy, amino, oxim or hydroxyl, and R.sup.41 represents hydrogen, C.sub.1-6 alkyl which may be optionally substituted, or a protective group for a carboxyl group.

Triazole intermediates for tricyclic benzazepine and benzothiazepine

A compound represented by the general formula (I) and a pharmaceutically acceptable salt and solvate thereof having an effect for inhibiting the agglutination of platelets is disclosed: ##STR1## wherein R.sup.1 represents a group --W--(CH.sub.2).sub.i --COOR.sup.3,

Compound with platelet aggregation inhibitor activity

Tricyclic benzazepine and benzothiazepine derivatives

Pyridine derivatives having angiotensin II antagonism

A novel benzothiazole or benzimidazole derivative represented by formula (I) ##STR1## wherein X represents a sulfur atom or a NH group; R.sup.1 represents a hydrogen atom, a lower alkoxy group, a chlorine atom, a bromine atom or an iodine atom; R.sup.2 represents a hydrogen atom a substituted or unsubstituted lower alkyl group, a vinyl group, an aryl group or an acyl group; m is an integer of 1, 2 or 3; and n is an integer of 0, 1 or 2, which shows an excellent acid secretion suppressing effect and gastric mucosa protecting effect, and an antiulcer agent containing the same as an active ingredient.

Benzothiazole and benzimidazole derivatives and antiulcer agent

Sugar lactams such as N-(3-phenylpropyl)-1-deoxynojirimycin, 1-deoxynojirimycin, D-glucaro-.delta.-lactam, 6-O-triphenylmethyl-D-gluco-.delta.-lactam, etc., and new derivatives thereof which inhibit metastasis of cancer cells.

Cancer cell metastasis inhibitor methods

Compounds of the general formula (I): ##STR1## and pharmaceutically acceptable salts thereof, in which A, B, C and D each represent --CH.dbd. or --N.dbd., with the proviso that at least one of them is --N.dbd.;

Azole derivatives and anti-ulcerative composition containing same

A piperidine compound represented by formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group having from 1 to 4 carbon atoms, a lower alkoxy group having from 1 to 4 carbon atoms, a hydroxymethyl group, --CO.sub.2 R.sup.3, or ##STR2## wherein R.sup.3 represents a hydrogen atom or a lower alkyl group having from 1 to 4 carbon atoms; R.sup.4 represents a hydroxyl group, a lower alkoxy group having from 1 to 4 carbon atoms or --NR.sup.6 R.sup.7 (wherein R.sup.6 and R.sup.7, which may be the same or different, each represent a hydrogen atom or a lower alkyl group having from 1 to 4 carbon atoms); and R.sup.5 represents a hydrogen atom, a lower alkanoyl group having from 1 to 4 carbon atoms, or a chlorobenzoyl group; R.sup.2 represents a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms, a substituted or unsubstituted benzyl group, or a (2,2,6,6-tetramethylpiperidin-1-yl)ethyl group; and n represents 0 or an integer of 1 or 2, and an antiulcer composition containing said piperidine compound.

Piperidine compounds and antiulcer composition containing the same

Compounds of the general formula (I): ##STR1## and pharmaceutically acceptable salts thereof, in which

Thiazolo [4,5-6] pyridine derivatives and anti-ulcerative composition

Cephalosporin compounds of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and are a hydrogen atom or a lower alkyl group of 1-5 carbon atoms and A is a hydrogen atom or a nucleophilic compound residue or pharmacologically acceptable salts thereof have excellent antibacterial activity against Gram positive and Gram negative microorganisms.

Cephalosporin compounds and antibacterial agents

Sugar lactams such as N-(3-phenylpropyl)-1-deoxynojirimycin, 1-deoxynojirimycin, D-glucaro-.delta.-lactam, 6-O-triphenylmethyl-D-gluco-.delta.-lactam, etc. and new derivatives thereof which markedly inhibit metastasis of cancer cells.

Cancer cell metastasis inhibitors and novel compounds

Growing community of inventors

Kawasaki, Japan

Takashi Tsuruoka