Fuji Electric Co., Ltd.

Organ Technologies, Inc.

Sanford Burnham Prebys Medical Discovery Institute

Japan Tobacco Inc.

Riken Corporation

Fuji Electric Holdings Co., Ltd.

Glytech, Inc.

Ricoh Company, Ltd.

Daiichi Sankyo Company, Limited

Kobayashi Pharmaceutical Co., Ltd.

Fuji Electric Systems Co. Ltd.

Kyocera Corporation

National Institute of Advanced Industrial Science and Technology

Nidek Co., Ltd.

Otsuka Chemical Holdings Co., Ltd.

Takashi Tsuji

Akimasa Kinoshita

Kenji Fukuda

Katsunari Tezuka

Anthony B Pinkerton

Yasuhiro Kajihara

Kazuhiro Fukae

Izumi Sakamoto

Kazuhisa Nakao

Koh-ei Toyoshima

Yoshiyuki Kobayashi

Osamu Suzuki

Takuya Ikeda

Nobuaki Hori

Takahiro Nagayama

Layton H Smith

Hiroaki Asai

Yuri Nambu

Naoki Miyoshi

Jun Tanaka

Noriyuki Iwamuro

Koichi Endo

Tsuyoshi Nakamura

Kosuke Tanaka

Mayuko Akiu

Mihoko Kawasaki

Hironori Tomi

Yukihiro Ogawa

Masayuki Ishihara

Koji Miyoshi

Masamitsu Oshima

Edward Hampton Sessions, Jr

Koji Terayama

Mika Yokoyama

Koh-Ei Toyoshima

Takeshi Fukuda

Naoki Tanaka

Hideki Kubota

Fumikazu Imai

Masatoshi Maeda

Kazuyuki Ishii

Takashi Saotome

Kazuto Miyazaki

Keisuke Tazuru

Atsushi Tanaka

Riki Goto

Naohiro Hayashi

Yoshiyuki Yonezawa

Yasunobu Kurosaki

Takeshi Kuribayashi

Ritsuko Morita

Nobuo Sakuragawa

Shun-Ichi Nakamura

Hiroyuki Fujisawa

Koutaro Ishibashi

Yutaka Mori

Oshima Masamitsu

Nakao Kazuhisa

Kyosuke Kishimoto

Kyosuke Asakawa

Miho Ogawa

Makoto Takeo

Edward Hampton Sessions

P-type contact regions are disposed apart from one another, and in a p-type base region, at least hole current regions directly beneath the contact regions have an impurity concentration of not more than 5×10/cm. A p-type region for mitigating electric field and disposed between adjacent gate trenches is separated into first portions in contact with the hole current regions and second portions in contact with only a portion of the base region other than the hole current regions. During conduction of body diodes, forward current flows into an n-type drain region through the contact regions, the hole current regions, and the first portions. Thus, in the drain region, holes from the base region are injected only into hole injection regions that are directly beneath the first portions, but are not injected into regions that respectively surround peripheries of the hole injection regions.

Silicon carbide semiconductor device

A semiconductor device includes: a high-concentration layer of a first conductivity-type provided on a drift layer of the first conductivity-type; a buried layer of a second conductivity-type provided in the high-concentration layer; an injection regulation region of the second conductivity-type provided on the high-concentration layer; a high-concentration region of the second conductivity-type provided inside the injection regulation region; a carrier supply region of the first conductivity-type provided at an upper part of the injection regulation region; and an insulated gate structure provided inside a trench, wherein a ratio of the impurity concentration of the injection regulation region to an impurity concentration of an upper part of the high-concentration layer is 0.5 or greater and 2 or smaller.

Insulated gate semiconductor device

The present invention provides a method for producing regenerated hair follicle primordium that allows production of regenerated hair follicle primordium more easily and in larger amounts compared to conventional production methods. A method for producing regenerated hair follicle primordium comprising a step of obtaining hair follicle primordium by culturing a first population of cells comprising epithelial cells and a second population of cells comprising mesenchymal cells while allowing them to be in contact is provided. The production method of the present invention is characterized in that at least either one of said first population of cells and said second population of cells has formed cell aggregates before said contact, and a culture support is not used when contacting the other population of cells with said cell aggregate.

Method for producing regenerated hair follicle primordium

The purpose of the present invention is to propose a method for measuring the level of health of a subject, with which it is possible: to perform health examination that is non-invasive to the human body and that employs a simple method; to provide highly reliable analysis results having a scientific basis; and to, additionally, provide appropriate solutions to the subject. Another purpose of the present invention is to propose a health-level determining apparatus employing said method and a new business model employing said method. The present invention is a method for measuring the level of health of a subject, including a hair analyzing step (A) for analyzing hair of the subject. It is preferable that the aforementioned hair analyzing step (A) include a step (A-1) for analyzing hair in the occipital region. In addition, it is preferable that the aforementioned hair analyzing step (A) include a step (A-2) for analyzing hair in a site other than the occipital region.

Health-level measuring method, health-level determining apparatus, and hair-health examination system

The present invention relates to a novel fused ring compound having urea structure that exhibits excellent NAMPT activating effect, and a method using the same for treating/preventing metabolic disorder, cardiovascular and kidney disease, mitochondrial disease, neurodegenerative disease, ocular disease, and muscle wasting disorder. The present invention provides a compound represented by following formula (I) or a pharmacologically acceptable salt:

Fused ring compound having urea structure

The present invention relates to a novel azole derivative as an apelin receptor agonist and a method for treating cardiovascular disease, diabetic disease, renal disease, hypertension, and arteriosclerosis, etc., using the same. The present invention provides a compound represented by formula (I) or a pharmacologically acceptable salt thereof wherein Xrepresents —N═ or —CH═, Xrepresents —CH═ or —N═, Rand Reach represent a Cto Calkoxy group or the like, Rrepresents a heteroaryl group (the heteroaryl group is optionally substituted by a methyl group or the like) or the like, and Rrepresents a Cto Calkylthio group or a Cto Calkenyl group (the Cto Calkylthio group and the Cto Calkenyl group are each optionally substituted by one carboxy group or the like) or the like.

Azole derivatives as apelin receptor agonist

The present invention relates to a compound or a pharmacologically acceptable salt thereof having excellent tissue non-specific alkaline phosphatase inhibitory activity. The present invention provides a compound represented by the following formula (I): wherein Xrepresents a nitrogen atom or CR, Rrepresents a hydrogen atom, a C-Calkyl group, or a C-Calkoxy group, Rrepresents a halogen atom, Rrepresents a hydrogen atom or a halogen atom, Rrepresents a hydrogen atom or a halogen atom, and Rrepresents a C-Calkylsulfonyl group, a substituted C-Calkyl group, a substituted C-Chaloalkyl group, a substituted C-Calkoxy group, or a substituted C-Calkylamino group, or a pharmacologically acceptable salt thereof.

Biaryl derivative

The present invention relates to a novel fused ring compound having urea structure that exhibits excellent NAMPT activating effect, and a method using the same for treating/preventing metabolic disorder, cardiovascular and kidney disease, mitochondrial disease, neurodegenerative disease, ocular disease, and muscle wasting disorder. The present invention provides a compound represented by following formula (I) or a pharmacologically acceptable salt: Formula (I) wherein A, B, R, Rand Rrepresent the same meanings as in the claims.

The present invention is directed to a hair growth agent for external use comprising chiro-inositol, which is provided as an excellent hair growth agent.

Hair growth agent

Provided are a hair observation method, a phase contrast microscope system, and a preparation. The hair observation method includes capturing an infrared image of the hair using an image sensor that is capable of detecting infrared light. A phase contrast microscope system includes: a stage having a sample placed thereon; an infrared light irradiation source for irradiating infrared light to the sample placed on the stage; an image sensor that is capable of detecting infrared light and configured to capture an infrared image of the sample; and a display apparatus configured to display the infrared image captured by the image sensor. The preparation includes a microscope glass and a plurality of hair pieces that are obtained by cutting one hair and arranged on the microscope glass in a manner parallel with one another from one end to another end in a cutting order.

Hair observation method, phase contrast microscope system, and preparation

The present invention relates to a novel azole derivative as an apelin receptor agonist and a method for treating cardiovascular disease, diabetic disease, renal disease, hypertension, and arteriosclerosis, etc., using the same. The present invention provides a compound represented by formula (I) or a pharmacologically acceptable salt thereof wherein Xrepresents &#x2014;N&#x2550; or &#x2014;CH&#x2550;, Xrepresents &#x2014;CH&#x2550; or &#x2014;N&#x2550;, Rand Reach represent a Cto Calkoxy group or the like, Rrepresents a heteroaryl group (the heteroaryl group is optionally substituted by a methyl group or the like) or the like, and Rrepresents a Cto Calkylthio group or a Cto Calkenyl group (the Cto Calkylthio group and the Cto Calkenyl group are each optionally substituted by one carboxy group or the like) or the like. 

A silicon carbide semiconductor device, including a semiconductor substrate having first and second epitaxial layers. The second epitaxial layer is formed on a first main surface of the semiconductor substrate, and includes first and second semiconductor regions, selectively provided in a surface layer of the second epitaxial layer respectively in the active region and the border region, and a third semiconductor region. The semiconductor device further includes a trench penetrating the first and third semiconductor regions to reach the first epitaxial layer, a gate electrode provided in the trench via a gate insulating film, a first electrode electrically connected to the first and third semiconductor regions, and a second electrode provided at a second main surface of the semiconductor substrate. The second semiconductor region is separate from the first semiconductor region. A portion of the third semiconductor region is exposed at the first main surface of the semiconductor substrate, between the first and second semiconductor regions.

The present invention relates to a novel azole derivative as an apelin receptor agonist and a method for treating cardiovascular disease, diabetic disease, renal disease, hypertension, and arteriosclerosis, etc., using the same. The present invention provides a compound represented by formula (I) or a pharmacologically acceptable salt thereof wherein Xrepresents &#x2014;NH&#x2550; or &#x2014;CH&#x2550;, Xrepresents &#x2014;CH&#x2550; or &#x2014;N&#x2550;, Rand Reach represent a Cto Calkoxy group or the like, Rrepresents a heteroaryl group (the heteroaryl group is optionally substituted by a methyl group or the like) or the like, and Rrepresents a Cto Calkylthio group or a Cto Calkenyl group (the Cto Calkylthio group and the Cto Calkenyl group are each optionally substituted by one carboxy group or the like) or the like. 

The object of the present invention is to provide a glycosylated polypeptide having uniform sugar chain structure which has interferon &#x3b2; activity. It was found that a glycosylated polypeptide having uniform sugar chain structure as well as having interferon &#x3b2; activity can be prepared by a method comprising a step of synthesizing a glycosylated peptide fragment and at least two peptide fragments and a step of linking the glycosylated peptide fragment and the at least two peptide fragments.

Glycosylated polypeptide and pharmaceutical composition containing same

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Nagareyama, Japan

Takashi Tsuji