Astellas Pharma Gmbh

Yamanouchi Pharmaceutical Company Ltd.

Takashi Toya

Satoshi Hayashibe

Masamichi Okada

Toshihiro Watanabe

Jiro Fujiyasu

Hirotsune Itahana

Tetsuo Kiso

Yukinori Nagakura

This invention relates to the provision of novel aminomethyl-substituted thiazolobenzimidazole derivatives represented by the following general formula (I) or a salt thereof. The aforementioned derivative or a salt thereof has a metabotropic glutamate receptor action and excellent oral activity and is therefore useful as a medicament. (In the formula, R: an oxygen-containing saturated hetero ring or the like, Alk: a lower alkylene, m: 0 or 1, Alk: a lower alkylene which may be substituted with oxo group, n: 0 or 1, X: a bond, O, S or NR, R: H or the like, and R, R, R, Rand R: the same or different from one another and each represents H or the like. Provided that Rdoes not represent a lower alkyl or a halogeno-lower alkyl when X is a bond and n is 1. Also, Rrepresents a group other than Me when m is 1, Ris OH or OMe and Alkis a Calkylene, and further 1) when X is a bond, n is 1 and Ris H, or 2) when X is a bond, n is 0 and Ris cyclohexane.)

Aminomethyl-substituted thiazolobenzimidazole compounds

This invention relates to pharmaceuticals for neuropathic pains comprising an mGluR1 receptor antagonist for systemic administration. Drugs efficacious in treating various neuropathic pain can be provided by the invention.

Pharmaceuticals for neurogenic pain

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Tsukuba, Japan

Takashi Toya