Kurita Water Industries Ltd.

Takashi Tomoda

Hiroshi Morita

Masato Yamaguchi

Isao Joko

Yoshiaki Motozato

Tetsuro Yamamoto

Masaaki Wakita

The separation material for separating and recovering a blood coagulation factor comprises a porous matrix having linked thereon one or more ligands each consisting of a radical exhibiting an affinity for the blood coagulation factor to be recovered, said matrix having a specific surface area of at least 1.5 m.sup.2 per milliliter of the separation material with respect to pores having diameters of at least 0.1 .mu.m and being derived from a porous particulate material having an exclusion limit molecular weight of at least 1.5.times.1.sup.6 as determined with polyethylene glycol. The separation material is prepared by the process steps of subjecting a porous particulate material having an exclusion limit molecular weight of at least 1.5.times.10.sup.6 to activation by 1,1'-carbonyldiimidazolating, tresylating, carbodiimidizing, thiopropylating, epoxidizing, bromocyanizing or formylating using the corresponding activating agent and reacting the so activated porous particulate material with one or more substances which exhibit after being linked as ligand on the porous particulate material, an affinity to the blood coagulation factor to be covered, so as to form a porous matrix having a specific surface area of at least 1.5 m.sup.2 per milliliter of the porous particulate material with respect to pores having diameters of at least 0.1 .mu.m.

Separation material derived from glucomannan for blood coagulation

A novel ion exchanger useful for universal ion-exchange purposes and, in particular, for ion exchanger for ion-exchange chromatography is proposed, said novel ion exchanger being obtained by introducing radicals of one or more ion-exchangeable groups into cross-linked glucomannan beads by a chemical treatment thereof. Such ion exchanger beads are superior in the compressive strength and permit a high flow rate of the liquid to be subjected to ion exchange through an exchange column packed with them.

Ion exchanger based on cross-linked glucomannan

Growing community of inventors

Ebina, Japan

Takashi Tomoda