Fujisawa Pharmaceutical Company, Ltd.

Astellas Pharma Gmbh

Takashi Tojo

Keiji Matsuda

Hidenori Ohki

Masataka Morita

Takayuki Inoue

Hiroshi Matsuda

Kohji Kawabata

Mitsuru Ohkubo

Kenji Murano

Kousei Yoshihara

David Barrett

Takahiro Matsuya

Nobuyuki Shiraishi

Akira Nagashima

Hiroshi Sasaki

Akira Tanaka

Shigehiro Takase

Hiroshi Hatanaka

Takashi Ogino

Seiji Hashimoto

Yasuhisa Tsurumi

Yasuhiro Hori

Yutaka Nakajima

Kazutoshi Sakamoto

Hiroaki Mizuno

Shohei Shirakami

Norio Hashimoto

Takeshi Hondo

Koichiro Mukoyoshi

Atsushi Kanda

Yasuyuki Higashi

Fumie Takahashi

Masaharu Ichihara

Hitoshi Sawada

Keiko Hatanaka

Atsushi Ohigashi

Akira Okimoto

The invention relates to compound of the formula (I) or its salt, wherein &#x2014;R, &#x2014;R, &#x2014;R, &#x2014;R, &#x2014;R, -M-, &#x2014;X&#x2014; and &#x2014;Y&#x2550; are as defined in the description, their use of as, medicament, the process for their preparation and use for the treatment of JAK3 mediated diseases. 

Heterocyclic Janus Kinase 3 inhibitors

A compound of the formula (I): R&#x2014;NH&#x2014;X&#x2014;Y-Z (I) wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof useful as a vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, a method for preventing or treating a VAP-1 associated disease, especially macular edema, which method includes administering an effective amount of the compound or a pharmaceutically acceptable salt thereof to a mammal, and the like.

Thiazole derivatives

This invention relates to new polypeptide compound represented by general formula (I), wherein R, R, R, R, Rand Rare as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on &#x3b2;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases includinginfection (e.g.pneumonia) in a human being or an animal.

Cyclic hexapeptides having antibiotic activity

The invention relates to new polypeptide compounds represented by the following formula &lsqb;I&rsqb;:

Echinocandine derivatives with antimicrobial activity

This invention relates to new polypeptide compounds represented by general formula (I), wherein R,, R,, R,and R,are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on &bgr;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including,infection (e.g.,pneumonia) in a human being or an animal.

Cyclic hexapeptides with antimicrobial activity

Growing community of inventors

Osaka, Japan

Takashi Tojo