Taiho Pharmaceutical Company Limited

Takashi Suzue

Setsuro Fujii

Katsuo Takikawa

Sadao Hashimoto

Toshihiro Hamakawa

Yoko Osame

Toshiaki Shibata

Ryuji Sakakibara

Hiroshi Minami

Yasushi Kurashige

Motoyoshi Kajihara

An oral antilipemic agent comprising a pharmaceutically effective amount of at least one of acidic polyamino acids having a molecular weight of 10,000 to 100,000 and pharmaceutically acceptable salts thereof, and an adjuvant.

Oral antilipemic agents

An N-substituted guanidino acid derivatives having the following formula of ##EQU1## wherein R is an alkyl having 6 to 15 carbon atoms,. a cycloalkyl having 6 to 15 carbon atoms or an aryl(C.sub.6 to C.sub.8)alkyl(C.sub.1 to C.sub.9); A represents R.sup.1 or R.sub.2 CO--, R.sup.1 being an alkyl having 1 to 4 carbon atoms, an alkenyl having 2 to 4 carbon atoms, cyclohexyl, a phenyl containing or not containing a substitute of a lower alkyl, a halogenated lower alkyl, a lower alkoxy, hydroxy or a halogen, or a benzyl containing or not containing a substitute of a lower alkyl, a halogenated lower alkyl, a lower alkoxy, hydroxy or a halogen, and R.sup.2 being an alkyl of 1 to 3 carbon atoms, an alkenyl of 2 to 3 carbon atoms, an aryl of 6 to 8 carbon atoms or an aryl(C.sub.6 to C.sub.8)alkyl(C.sub.1 to C.sub.2); and n is an integer of 4 to 10. The present compounds are excellent in pharmacological activities, particularly in antagonism to bradykinin and histamine, and useful as anti-inflammatory agent.

N-substituted guanidino acid derivatives

Growing community of inventors

Naruto, Japan

Takashi Suzue