Meiji Seika Kaisha, Ltd.

Takashi Shomura

Shigeharu Inouye

Taro Niida

Michio Kojima

Tomizo Niwa

Hiroshi Watanabe

Masaji Sezaki

Yasuaki Ogawa

Takashi Tsuruoka

Yujiro Yamada

Shoji Omoto

Kazunori Ohba

Yasumitsu Kondo

Shigeharu Inoue

Norio Ezaki

Takashi Hisamatsu

Tatsuo Ito

Kazuo Saito, Deceased

Shinichi Kondo

Katsuyoshi Iwamatsu

Toru Sasaki

Tetsuro Watanabe

Shinji Miyadoh

Harumi Fukuyasu

Chuhei Nojiri

Tadashi Nakazawa

Shinji Miyado

Jiro Itoh

Yuzo Kazuno

Hitoshi Goi

Shingo Uchida

Hiroomi Watabe

Akira Suzuki

Masaru Shimura

Seiji Shibahara

Yoshikazu Sato

Masao Koyama

Nobuto Minowa

Shuichi Gomi

Takashi Yaguchi

Haruo Yamamoto

Tomoya Machinami

Yasuharu Sekizawa

Michiaki Iwata

Tetsutaro Niizato

Shoichi Amano

Shigeharu Inoye

Masayuki Takagi

Tadaaki Okada

Mieko Nagasawa

Junko Yoshida

Naotoshi Akai

Takao Shimizu

Kazuo Okano

Shigetaka Ishii

Tatsuo Itoh

Kazunori Oba

Shigeharu Inoje

Kazuo Saito

Kei-ichi Imamura

Kunikazu Totsukawa

Hiromi Toyama

Masashi Niida

Shiro Sakakibara

Singo Uchida

Kunikazu Totsugawa

Zenichiro Ohya

Katsuo Kawakami

Takahiko Kikuchi

2,3-disubstituted-4-hydroxyquinoline derivatives of the general formula (I): ##STR1## [wherein R.sup.1 represents a hydrogen atom or R.sup.3 CO-- (wherein R.sup.3 is a lower alkyl group); R.sup.2 represents a hydrogen atom, --CH.sub.3 or --C.sub.2 H.sub.5 ; A represents ##STR2## and W represents a hydrogen atom, or 1- 4 halogen atoms or alkyl groups which are substituted at the nucleus and may be the same or different] have a strong antagonistic action on leukotriene D.sub.4.

2,3-disubstituted-4-hydroxyquinoline derivatives

A novel substance having anthelmintic activity, the PF 1022 substance, which is produced by cultivating a fungal strain capable of producing the substance and recovering the substance from the culture.

PF 1022 substance, method of treating helminthic parasitic infection and

A novel compound having an intense insecticidal activity and a process for producing the same which comprises culturing a strain belonging to the genus Humicola and isolating the compound from the culture.

Compound having insecticidal activity and insecticide composition

Novel substances exhibiting antimicrobial activity and antitumor activity, a process for producing them by cultivating a microorganism belonging to the genus Streptomyces and capable of producing them and derivatives of such substances.

Certain anti-tumor duocarmycin antibiotics from streptomyces

An antibiotic substance represented by formula (I) ##STR1## or a pharmaceutically acceptable salt thereof, which is produced by cultivating a microorganism belonging to the genus Streptomyces and isolating the substance from the cultured cells.

Novel antitumor antibiotic substance and a method for production thereof

Novel antibiotic SF-2288 is produced by fermentation of an actinomycete belonging to the genus Actinomadura in nutrient medium. Based on its physico-chemical and biological properties, antibiotic SF-2288 possesses an excellent antimicrobial activity against Gram-positive and Gram-negative microorganisms and antiviral activity.

Antibiotic SF-2288 and its preparation method

Disclosed is an antiviral agent comprising as an active component a substance SF-2140 described in detail in the specification, and a pharmaceutically acceptable carrier. Also disclosed is a method for treatment of viral diseases comprising administering a pharmaceutically effective amount of the substance SF-2140.

Antiviral agents

Essentially pure plasmids derived from Actinomycetes are described which have at least one restriction cleavage site for specific restriction enzyme and have molecular weight of less than 1.0.times.10.sup.7.

Plasmids derived from Actinomycetes

An antibiotic SF-2103A substance or a salt thereof, and a process for the production thereof are described, and the process comprises cultivating an antibiotic SF-2103A substance-producing strain in a nutrient medium and recovering the desired substance from the culture broth.

Antibiotic SF-2103A substance and process for production thereof

Disclosed is a novel antibiotic SF-2107 series substance consisting essentially of Substance SF-2107 A-1, Substance SF-2107 B and/or Substance SF-2107 C, each having the phisico-chemical properties as described in the specification, which substance exhibits an antibacterial activity against both gram-positive and gram-negative bacteria and is useful for pharmaceuticals, bactericides, disinfectants, etc. Also disclosed is a process for preparing the substance.

Novel antibiotic SF-2107 series substance and process for preparing the

Antibiotics, designated as SF-2080A substance and SF-2080B substance, are described, and are obtained by cultivating an SF-2080 substance-producing strain belonging to the genus Streptomyces, for example, Streptomyces sp. SF-2080 (FERM-P No. 5072, ATCC No. 31673), in a nutrient medium, and recovering the desired substance from the culture.

Antibiotic substances and processes for production thereof

A new antibiotic SF-1130-x.sub.3 substance is produced by cultivating a microorganism Streptomyces myxogenes SF-1130 (deposited under FERM-P. 676 and ATCC 31305) in a liquid culture medium under aerobic conditions, and this antibiotic may be isolated from the fermentation broth of said microorganism and is useful as an inhibitor to .alpha.-glucosidase and saccharase. Besides, this antibiotic, when orally given, is useful as a drug for suppressing an elevation in the level of blood sugar in living animals which have taken starch and/or sugars.

Antibiotic SF-1130-x.sub.3 3 substance and production and use thereof

New antibiotic, SF-2052 substance is produced by cultivating a microorganism, Dactylosporangium matsuzakiense SF-2052 now deposited under FERM-P 4670 or ATCC No. 31570 in a liquid culture medium under aerobic conditions, and this antibiotic may be isolated from the culture broth by conventional method and is useful as antibacterial agent.

Antibiotic SF-2052 substance and production and use thereof

L-2-Amino-4-methylphosphinobutyric acid (L-MPGA) which is useful as bactericide and herbicide can be prepared by optical resolution of its racemic mixture, D,L-MPGA with the action of a microbial acylase. The process comprises providing D,L-MPGA in the form of its N-acyl derivative, reacting N-acyl-D,L-MPGA in an aqueous medium with a microbial acylase having an optically specific hydrolytic activity, whereby selectively eliminating the acyl group of N-acyl-L-MPGA to give a mixture of L-MPGA and N-acyl-D-MPGA and isolating L-MPGA from the mixture. The acylase is produced by cultivating a microbial strain belonging to the genus Pseudomonas, Streptomyces or Aspergillus, particularly Pseudomonas maltophilia BN-233, Streptomyces violascens SF 2072, Streptomyces diastatochromogenes SF 2073, Aspergillus sp. KS-101 or Aspergillus sp. KS-102.

Process for the optical resolution of

New antibiotics, SF-2050 substance and SF-2050B substance are produced by cultivating a microorganism Streptomyces sp. SF-2050 now deposited under FERM-P 4358 and under ATCC. 31450 in a liquid culture medium under aerobic conditions, and these antibiotics may be isolated from the fermentation broth and useful as an antibacterial agent. These antibiotics have an activity inhibitory to .beta.-lactamase.

Antibiotics SF-2050 and SF-2050B substances and production and use

Growing community of inventors

Yokohama, Japan

Takashi Shomura