Sankyo Company, Limited

Takashi Shiokari

Seigo Ueda

Masayuki Iwata

Tomihisa Yokoyama

Kunio Hashi

Akira Kusai

Yukinori Kawahara

An intraocular tension lowering composition for topical administration is disclosed which comprises an effective amount of an (i) angiotensin II antagonist, (ii) a boric aid and (iii) an ethylenediamine tetraacetic acid. Said composition has excellent intraocular tension lowering activity. Said composition may be effectively administered to humans and other warm-blooded animals to lower intraocular tension.

Intraocular tension lowering compositions for topical administration

In a freeze-drying method for producing a dried pharmaceutical compound or preparation, a first liquid is frozen, a second liquid is added to the frozen first liquid and is frozen thereon, and the frozen first and second liquids are freeze-dried together, in which at least one of said first and second liquids contains said pharmaceutical compound of preparation dissolved or suspended therein. The other liquid or liquids may be pure solvent (generally water) or may contain one or more other substances.

Method of preparing a freeze-dried formulation containing a drug

Administration of an N-acylated amino acid in association with a penem or carbapenem antibiotic relieves or eliminates the renal problems associated with administration of the antibiotic alone. The amino acid derivative and antibiotic may be formulated together as a composition or administered separately, either simultaneously or sequentially.

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Saitama, Japan

Takashi Shiokari