Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo

Hayashibara Co., Ltd.

Seibutsu Kagaku Kenkyujo

Kabushiki Kaisha Hayashibara

Kabushiki Kaisha Hayashibara Seibutsu

Hayashibara Seibutsu Kagaku Kenkyujo Kabushiki Kaisha

Takashi Shibuya

Toshio Miyake

Toshiyuki Sugimoto

Shigeharu Fukuda

Seisuke Izawa

Hajime Aga

Shuzo Sakai

Hiroto Chaen

Takahiko Mandai

Tomoyuki Nishimoto

Kazuyuki Oku

Yoshikatsu Miwa

Katsuhide Okada

Masaru Yoneyama

Satoshi Iritani

Takeshi Ario

Tatsuya Ishihara

Akiko Miyake

Shoichi Hamada

Masaki Miyake

Yasuo Takeuchi

Hitomi Wake

Akihiko Tabuchi

The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.

Process for producing a particulate composition comprising an hydrous crystalline 2-o-alpha-d-glucosyl-ascorbic acid

A process for enabling the production of a particulate composition containing crystalline trehalose dihydrate is provided. Including allowing an &#x3b1;-glycosyltrehalose-forming enzyme to act on liquefied starch derived from a microorganism of the genusand a trehalose-releasing enzyme derived from a microorganism of the genusalong with a starch debranching enzyme and a cyclomaltodextrin glucanotransferase; allowing glucoamylase to act on the resulting mixture to obtain a saccharide solution containing &#x3b1;,&#x3b1;-trehalose; precipitating crystalline &#x3b1;,&#x3b1;-trehalose dihydrate from the above saccharide solution; collecting the precipitated crystalline &#x3b1;,&#x3b1;-trehalose dihydrate by a centrifuge; and ageing and drying the collected crystals. Cyclomaltodextrin glucanotransferase derived from a microorganism of the genusor a mutant enzyme thereof is used to increase the &#x3b1;,&#x3b1;-trehalose content in the saccharide solution to over 86.0% by weight, on a dry solid basis, without passing through a fractionation step by column chromatography.

Process for producing a particulate composition comprising crystalline &#x3b1;,&#x3b1;-trehalose di-hydrate

Process for producing a particulate composition comprising crystalline alpha, alpha-trehalose di-hydrate

The present invention has an object to provide an external dermal composition for anti-ageing, which prevents or improves apparent skin problems such as wrinkles, fine wrinkles, blemishes, and saggings caused by increasing age or ageing; and maintains or improves the barrier function and the hyaluronic acid production in the skin. The object is solved by providing an external dermal composition for anti-ageing, which contains an aqueous medium as a base material and one or more ingredients selected from L-ascorbic acid, derivatives thereof, and their salts as an effective ingredient(s).

External dermal composition for anti-ageing and method for producing the same

Process for producing a particulate composition comprising an hydrous crystalline 2-O-&#x3b1;-D-glucosyl-L-ascorbic acid

Process for producing a particulate composition comprising crystalline trehalose dihydrate

Process for producing a particulate composition comprising anhydrous crystalline 2-O-alpha-D-glucosyl-L-ascorbic acid

The present invention has objects to provide a novel crystalline 2-O-&#x3b1;-glucosyl-L-ascorbic acid and its production process and uses, and solves the above objects by providing hydrous crystalline 2-O-&#x3b1;-glucosyl-L-ascorbic acid, a particulate composition containing hydrous crystalline 2-O-&#x3b1;-glucosyl-L-ascorbic acid, and their production processes and uses.

Hydrous crystalline 2-O-&#x3b1;-D-glucosyl-L-ascorbic acid, particulate composition comprising the same, their preparation and uses

The present invention aims to provide a particulate composition containing anhydrous crystalline 2-O-&#x3b1;-D-glucosyl-L-ascorbic acid having a significantly, hardly solidifiable property compared to conventional ones in a grade for use in quasi-drugs; a process for producing the same; and uses thereof. The present invention solves the above object by providing a particulate composition containing anhydrous crystalline 2-O-&#x3b1;-D-glucosyl-L-ascorbic in an amount of over 98.0% by weight but less than 99.9% by weight, on a dry solid basis; or a degree of crystallinity of 90% or higher for anhydrous crystalline 2-O-&#x3b1;-D-glucosyl-L-ascorbic acid; and by providing a process for producing the same and uses thereof.

Particulate composition containing anhydrous crystalline 2-O-alpha-D-glucosyl-L-ascorbic acid, process for producing the same, and uses thereof

A reduction inhibitory agent for active-oxygen eliminating activity comprises trehalose as an effective ingredient. A method for inhibiting the reduction of active-oxygen eliminating activity comprises incorporating either trehalose or the reduction inhibitory agent into plant edible products and/or plant antioxidants. A composition is provided that reduces the active-oxygen eliminating activity of plant edible products and/or plant antioxidants.

Reduction inhibitory agent for active-oxygen eliminating activity

The object of the present invention is to provide a powdery product comprising crystalline &#x3b2;-maltose monohydrate which is powderized by spray method, and has a high-solubility in aqueous solvents and a satisfactory handleability, and to its preparation and uses. The present invention solves the above object by establishing a powdery product comprising crystalline &#x3b2;-maltose monohydrate which comprises 7% (w/w) or more but less than 14% (w/w) &#x3b1;-anomeric maltose, and has a crystallinity of 62% or more but less than 72%; a process for producing thereof which comprises the steps of producing a massecuite from an aqueous maltose solution comprising 86% (w/w) or more but less than 93% (w/w) of maltose and 2% (w/w) or more of glucose, on a dry solid basis, powderizing by a spray method, keeping in a relatively low humidity and a relatively high temperature, and further keeping in a relatively high humidity- and a relatively low temperature-condition; and uses thereof for various compositions such as foods, cosmetics, and pharmaceuticals.

Powdery product comprising crystalline &#x3b2;-maltose monohydrate, its preparation, and uses

Powder comprising water-containing &#x3b2;-maltose crystals and production process and use thereof

Growing community of inventors

Okayama, Japan

Takashi Shibuya