Honda Motor Co., Ltd.

Riken Corporation

Pioneer Corporation

Adv Antest Corporation

Takeda Pharmaceutical Company Limited

Sysmex Corporation

Suntory Holdings Limited

The Jikei University

Animal Allergy Clinical Laboratories Inc.

Takashi Saito

Takashi Sasaki

Hidetoshi Oishi

Akihiro Suzuki

Hirotoshi Inoue

Takaomi Saido

Nobuhisa Iwata

Hiroyuki Abe

Naoyuki Taniguchi

Tatsuya Fukuda

Yasushi Kojima

Mikako Shirouzu

Hiromi Oshima

Tsuyoshi Eguchi

Yasunori Suzuki

Eiji Miyoshi

Kenichi Masuda

Soichi Kojima

Tomokazu Matsuura

Toshitada Takemori

Takehisa Matsumoto

Chiemi Tsumagari

Takahiro Masaki

Ikuyo Inoue

Masahiro Miura

Takahiro Suemoto

Jiro Takano

Satoshi Tsubuki

Yoshie Takaki

Tadashi Nakaya

Kozo Suto

The present invention provides an antibody specific to IgE antibody-producing B cells or an antibody binding fragment thereof. More specifically, the present invention provides an isolated monoclonal antibody or an antigen binding fragment thereof that binds to a peptide having a sequence consisting of an amino acid sequence set forth in SEQ ID NO: 1 or 18, and

Anti-IgE antibody specifically binding to membrane-bound IgE antibody of IgE antibody-producing B cells and method for diagnosing and treating allergic symptoms using the same

Disclosed is an isolated monoclonal antibody against a human Transforming Growth Factor-&#x3b2; (TGF-&#x3b2;) Latency Associated Protein (LAP) degradate, the isolated monoclonal antibody being capable of recognizing an integrin binding site in the human TGF-&#x3b2; LAP degradate.

Antibody against human TGF-&#x3b2; LAP degradate, and use thereof

The above security device determines whether there occurs screening between a movable body such as a vehicle and a user, and controls the security level in accordance with the determination result. Specifically, the security device sets the security level high when there occurs screening between the movable body and the user, and sets the security level low when there occurs no screening.

Security device, security control method, program, and storage medium

A gas sensor which includes walls delimiting a gas detection chamber, and having an introduction port (or an inlet) through which an observed gas is introduced into the gas detection chamber, a measuring element disposed in the gas detection chamber and measuring concentration of a subject gas contained in the observed gas, and a heater constituting at least a portion of the walls, the portion facing the gas detection chamber.

Gas sensor

The present invention provides a non-human model mammal of Alzheimer's disease (AD) containing chimeric amyloid precursor protein (APP) gene capable of producing human amyloid &#x3b2; peptide (A&#x3b2;) or a living part thereof, characterized in that A&#x3b2;42/A&#x3b2;40 ratio at 8-weeks-old is about 7-fold or more (about 140-fold or more in homozygote) higher compared to that of a corresponding wild-type mammal. Moreover, the present invention provides the mammal or a living part thereof, further characterized in that the level of APP expression is not significantly different compared to the corresponding wild-type mammal, and a screening method for a prophylactic and/or therapeutic drug for AD, a biomarker in biological fluids and molecular imaging of amyloid deposition or other pathological changes in the brain for an early diagnosis of AD using the mammal or a living part thereof.

Model mouse of Alzheimer's disease expressing FAD APP 716 and use thereof

The present invention provides a peptide or protein having a neovascularization action and containing a basic amino acid cluster region of &#x3b2;1,6-N-acetylglucosaminyltransferase, a neovascularization accelerator containing the above-mentioned peptide or protein, a method of screening an inhibition substance for the above-mentioned peptide or protein, and a neovascularization inhibitor containing this inhibition substance.

Glycosyltransferase GnT-V having neovascularization action

The present invention provides a method of measuring the activity of neprilysin, etc. More specifically, the present invention provides a method of measuring the activity of neprilysin in nerve cells; a method of screening a protein, a peptide or a compound enhancing the activity or expression of neprilysin nerve cells by measuring the activity of neprilysin; a method of enhancing the activity or expression of neprilysin; and so on. Thus, the compound enhancing the activity and/or expression of neprilysin, which is obtained by the screening method characterized by using the method of measuring the activity of neprilysin in accordance with the present invention, is useful as a preventive and/or therapeutic agent for Alzheimer's disease. The method of measuring the activity of the present invention can be used for presymptoms diagnosis of Alzheimer's disease.

Method of measuring neprilysin activity

A gas sensor disposed on a wall of a gas passage, the gas sensor including: a gas detector detecting a target gas contained in the gas flowing in the gas passage; a detector which houses therein the gas detector and has a gas chamber into which the gas is introduced; and a cutoff valve controlling the introducing of the gas into the gas chamber from the gas passage.

Gas sensor, gas sensor system, and controlling method thereof

A gas detection chamber in which a gas sensing element is provided to detect a component of a gas allowed into the gas detection chamber is heated by a heater, and an output of the heater is regulated by a heater regulator. The heater regulator is adapted to cause the heater to continue to heat the gas detection chamber (preferably but not necessarily, the output of the heater is caused to lower) when an anomaly detection device detects an anomaly of the gas sensing element.

Gas detection apparatus and method

A gas sensor includes a gas detection chamber into which a detection gas is introduced, a detecting element and a compensating element each disposed in the gas detection chamber, a detection device which detects the concentration of a detection target gas contained in the detection gas, in accordance with a difference in electrical resistance values between the detecting element and the compensating element, and a dehumidifying element which is provided in the gas detection chamber, and reversibly absorbs water contained in the detection gas and drains off the water absorbed in the dehumidifying element.

Gas sensor and control method therefor

A first gas sensing element is provided in a first position to measure a concentration of a gas continuously, and a second sensing element is provided in a second position to measure the concentration of the gas intermittently. The second position is in close proximity to the first position. A deterioration determination unit is connected with the first and second sensing elements to make a determination as to whether the first sensing element becomes deteriorated, by comparing output values from the first and second sensing elements. A power controller is configured to supply the second sensing element with electric power throughout waiting periods during which the second sensing element stops measuring the concentration of the gas, and an amount of the electric power supplied throughout waiting periods is smaller than that supplied throughout operating periods during which the second sensing element continuously measures the concentration of the gas.

Gas detection apparatus and method for controlling gas sensor

The gas detecting system of the present invention is equipped with a catalytic combustion type gas sensorand a semiconductor type gas sensor, in a gas detecting systemhaving an operating sate in which generation of electricity is performed, and an idling state, at the time of the operating state, detection of the detection target gas is performed by the catalytic combustion type gas sensor, whereas at the time of the idling state, detection of the detection target gas is performed by the semiconductor type gas sensor

Gas detecting apparatus, gas detecting method and fuel cell vehicle

A degradation diagnosis method for simply performing degradation diagnosis of a gas sensor such as a hydrogen sensor. The hydrogen sensor has a reference detector member and common detector member, with each detector member respectively constituted of a detector element and temperature compensating element that form a pair. Power is normally supplied to the common detector member, which performs concentration detection of the hydrogen gas. When performing degradation diagnosis of this common detector member, concentration detection is performed simultaneously by each detector member for the gas of the prescribed hydrogen concentration by supplying power to both the common detector member and reference detector member and comparing the output value of the common detector member and the output value of the reference detector member.

Method and device for diagnosing gas sensor degradation

A control device determines whether or not the detected value of a unit conducting current output from a current sensor at least plural times is equal to or greater than a predetermined upper limit current at time of the start of the actuation of a gas sensor, and furthermore, determines that each of the units of the gas sensor is set in an abnormal state if a duration for a state in which it is determined that the detected value of the unit conducting current is equal to or greater than the predetermined upper limit current is equal to or longer than a predetermined upper limit time. On the other hand, if the duration for the state in which it is determined that the detected value of the unit conducting current is equal to or greater than the predetermined upper limit current is shorter than the predetermined upper limit time, it is determined that the detected value of the unit conducting current temporarily becomes equal to or greater than the predetermined upper limit current and each of the units is set in a normal state.

Growing community of inventors

Saitama, Japan

Takashi Saito