Shiseido Company, Limited

Keio University

Takashi Oka

Reiji Miyahara

Yuichiro Mori

Tetsuro Yonezawa

Makoto Uyama

Saori Tanabe

Kazuyuki Miyazawa

Michihiro Yamaguchi

Toshio Yanaki

Norio Ueno

Haruma Kawaguchi

Katsuhiko Yagi

Takashi Teshigawara

Takuya Saiwaki

Miho Yajima

Masaki Ujihara

Tomoaki Terada

Noriko Ohira

Akiko Sudo

Ryo Furukawa

Saori Nishikawa

Toyoko Imae

Xiaojuan Wang

The purpose of the present invention is to provide a two-component cosmetic which, when a first formulation and a second formulation are sequentially applied, forms a uniform gel film on the skin while imparting a feeling of moisture permeating the skin, thereby providing an ideal skin feel. The present invention pertains to a two-component cosmetic containing: (1) a first formulation containing a gel formation-promoting substance; and (2) a second formulation containing a gel-forming substance. The two-component cosmetic is characterized in that the first formulation is applied to the skin, and then the second formulation is applied thereto.

Two-component cosmetic

The present invention provides an &#x3b1;-gel forming composition and an &#x3b1;-gel composition that uses an &#x3b1;-gel formation composition that is highly stable and that does not become colored or deposit crystals, etc. over time. An &#x3b1;-gel composition includes (A) 25-50 mass % of one or more higher aliphatic alcohol and/or higher fatty acid has 16 or more carbons, (B) 40-70 mass % of a specific polyoxyethylene sterol ether, and (C) 5-20 mass % of a specific polyoxyethylene dialkyl ester and/or ether. The &#x3b1;-gel composition is generated by adding water.

Alpha-gel forming composition and alpha-gel composition

The present invention addresses the problem of providing an &#x3b1;-gel formation composition and an &#x3b1;-gel composition that uses the &#x3b1;-gel formation composition, wherein said compositions are highly stable, do not deposit crystals, become more viscous over time, and, when used in a preparations for external use, are refreshing during application and have high skin-moisturizing action after application. A gel composition that includes a polyoxyethylene dialkyl ester and/or a polyoxyethylene dialkyl ether, a polyoxyethylene alkyl ester and/or a polyoxyethylene alkyl ether, and, preferably, a polyoxyethylene sterol ether and water.

Alpha-gel formation composition, external skin care composition using alpha-gel formation composition, and alpha-gel composition using alpha-gel formation composition

A substrate mimicking intercellular lipids in stratum corneum consisting of a substrate and a lipid membrane formed on the substrate, wherein the lipid membrane is formed from ceramide, palmitic acid and cholesterol, and the ceramide, palmitic acid and cholesterol are present at a mass ratio of 20-70%:10-60%:20-40% (ceramide:palmitic acid:cholesterol).

Substrate mimicking intercellular lipids in stratum corneum and method of evaluating skin roughening using the same

The present invention provides a film composition effective for correcting irregularities on the skin surface, which has stretchability and flexibility as a result of crosslinkable protein microparticles in the film composition being crosslinked by transglutaminase, as well as superior air permeability and moisture evaporation properties as a result of forming a film with the crosslinkable protein microparticles.

Transglutaminase crosslinked protein microparticle film composition

The present invention provides: an oil-in-water emulsion composition, into which an oil-soluble drug is stably incorporated and which is excellent in feeling during use; and a method for producing the aforementioned composition, which does not require complicated operations. An oil-in-water emulsion composition comprising; (A) a polyoxyethylene phytosterol, (B) a glycerin fatty acid diester, (C) a polyoxyethylene-polyoxypropylene random copolymer dialkyl ether, (D) an oil-soluble drug, (E) oil, and (F) water; wherein a layered gel structure composed of the components (A) and (B) is present in an emulsion particle in the emulsion composition.

Oil-in-water emulsion composition and method for producing the same

The present invention provides an ophthalmic pharmaceutical composition containing acetylated hyaluronic acid and a pharmacologically acceptable carrier. Preferably, the average molecular weight of the acetylated hyaluronic acid is 10,000 to 1,000,000, and the acetyl group substitution number is from 2.0 to 4.0. In a preferred embodiment, this ophthalmic pharmaceutical composition is used in the treatment or prevention of dry eye, and in an even more preferred embodiment it is a dry-eye instillation.

Medicinal composition for ophthal use containing acetylated hyaluronic acid

A polysiloxane having a phosphorylcholine group represented by the following general formula (1).  To develop a method to obtain a polysiloxane having a phosphorylcholine group with ease and great versatility and provide a polysiloxane having a phosphorylcholine group in order to obtain a polysiloxane that has a wide range of application as a biocompatible material and a cosmetic material.

Polysiloxane having phosphorylcholine group and process for producing the same

Low molecular weight acetylhyaluronate, skin-softening composition,

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Yokohama, Japan

Takashi Oka