Nec Solution Innovators, Ltd.

Kanagawa Prefectural Hospital Organization

Juntendo Educational Foundation

Takashi Ohtsu

Yoshihide Hayashizaki

Iwao Waga

Jou Akitomi

Shintarou Katou

Shotaro Tsuji

Hiromi Takenaka

Satoru Takeda

Naomi Hirabayashi

Yasuhisa Terao

Hisamori Kato

The present invention provides a prediction device, a prediction method, a program, and a recording medium, with which whether or not desired aptamer sequences are enriched can be predicted easily. The prediction device of the present inventionincludes an input unit, a calculation unit, and a prediction unit. The input unitis a unit through which sequence information on a target aptamer sequence group including selected aptamers in a target pool and a reference aptamer sequence group including reference aptamer sequences are inputted. The calculation unitcalculates the free energy of the target aptamer sequence group and the free energy of the reference aptamer sequence group. The prediction unitcompares the free energy of these sequence groups, and predicts that the target pool is an enriched pool when the free energy of the target aptamer sequence group is lower than the free energy of the reference aptamer sequence group. The reference aptamer sequence group is a candidate aptamer sequence group including a plurality of candidate aptamer sequences or a virtual aptamer sequence group that is derived from the target aptamer sequence group and includes virtual aptamer sequences having the same base composition as the target aptamer sequence group.

Prediction device, prediction method, program, and recording medium

An aptamer capable of binding to a histidine peptide is provided. A nucleic acid used as the aptamer capable of binding to a histidine peptide may be a nucleic acid containing the base sequence of SEQ ID NO: 17, SEQ ID NO: 18, or containing a base sequence obtained by substitution, deletion, addition, or insertion of one or more bases in SEQ ID NO: 17 or 18.

Aptamer that recognizes peptide

A nucleic acid molecule that can bind to HMGB1 protein and applications thereof are provided. A nucleic acid molecule having a dissociation constant for HMGB1 protein of 5&#xd7;10or less can be used as the nucleic acid molecule that can bind to HMGB1 protein. The HMGB1 binding nucleic acid molecule can bind to HMGB1 protein that is known to be a cause of diseases such as cancer and inflammation, and it is therefore possible to obtain an effect to prevent and an effect to treat such diseases by allowing the HMGB1 binding nucleic acid molecule to bind to HMGB1 protein in a living body.

HMGB1 binding nucleic acid molecule and applications thereof

The present invention provides a nucleic acid molecule capable of binding to c-Met as a substance that can be used for clarification of the pathogenic mechanism of diseases caused by c-Met, diagnosis and treatment of the diseases, and the like, and also the use thereof. The c-Met binding nucleic acid molecule of the present invention is any one of the following nucleic acid molecules (A1), (A2), (B1), and (B2).

Nucleic acid molecule capable of binding to c-Met and use thereof

Growing community of inventors

Yokohama, Japan

Takashi Ohtsu