Fujisawa Pharmaceutical Company, Ltd.

Dainippon Sumitomo Pharma Co., Ltd.

Fuji Paudal Conmpany Limited

Takashi Nakajima

Masayoshi Murata

Keiji Matsuda

Hideo Tsutsumi

Kohji Hattori

Toshio Kanai

Hitoshi Fujita

Toshinari Sugasawa

Ichiro Koizumi

Hohji Hattori

Hideo Tsutumi

Tadatoshi Yamamoto

In a spheronizer for transforming columnar granulated product, which is fed in a wet condition, into spherical shapes, irregularities on a top surface of a particle-regulating disc are easily clogged, in particular, in an outer circumference. In view of this, a cleaning device () is provided for rapidly and reliably removing wet powders adhering to the particle-regulating disc. The cleaning device () is provided with a cover () covered on a part of the outer circumference of a rotating particle-regulating disc. The cover () is formed with a nozzle (). The nozzle () injects a fluid to a cleaning target surface covered with the cover (). The fluid in a space formed between the cover () and the cleaning target surface is suctioned and discharged from a vacuum connection port () to the outside.

Cleaning device and fine-particle processing device therewith

Disclosed is a method for the prevention and/or treatment of a chronic obstructive pulmonary disease by administrating a 5-membered cyclic compound represented by the formula below: or a pharmaceutically acceptable salt of the compound or a prodrug of the compound or salt: wherein X represents an oxygen or sulfur atom; Rrepresents a hydrogen atom, a substituted or unsubstituted alkyl or the like; Rrepresents a hydrogen atom, a substituted or unsubstituted alkyl or the like; Yrepresents single bond, a substituted or unsubstituted alkylene or the like; the wavy line means an (E) or (Z) coordination; Rrepresents a hydrogen atom, a substituted or unsubstituted aryl or the like; Yrepresents a substituted or unsubstituted alkylene or an alkenylene; Rrepresents a hydrogen atom, a substituted or unsubstituted alkanoyl or the like; and Rrepresents a hydrogen atom or a substituted or unsubstituted alkyl.

Therapeutic agent for chronic obstructive pulmonary disease

Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents

Novel 3-pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds and processes for their preparation are disclosed. These novel compounds have antimicrobial activity, and are useful as a medicament in the treatment of infectious diseases in human beings and animals.

3-pyrrolidinylthio-1-azabicyclo-[3.2.0]hept-2-ene-2-carboxylic acid

The present invention concerns intermediates in the preparation of novel 3-pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds and pharmaceutically acceptable salts thereof. The novel 3-pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds and pharmaceutically acceptable salts thereof show antimicrobial activity.

3-pyrrolidinylthio-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylic acid

The invention relates to compounds of the formula: ##STR1## in which R.sup.4 is an unsaturated, 5 or 6-membered heteromonocyclic group,

Intermediates for the preparation of compounds of antimicrobial activity

Novel 3-pyrrolidinylthio-1-azabiycyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds and pharmaceutically acceptable salts thereof have antimicrobial activity and are useful as medicaments in the treatment of infectious diseases caused by pathogenic microorganisms.

3-Pyrrolidinylthio-1-azabicyclo-[3.2.0]hept-2-ene-2-carboxylic acid

3-thio pyrrolidines are intermediates for carbapenams.

3-pyrrolidinylthio-1-azabicyclo-(3.2.0)hept-2-ene-2-carboxylic acid

The invention relates to a compound of antimicrobial activity, of the formula: ##STR1## in which R.sup.1 is carboxy or protected carboxy,

3-pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid

3-pyrrolidinylthio-1-azabicyclo[3.2.0]hepten-2-ene-2-carboxylic acid derivatives are prepared.

3-pyrolidinylthio-1-azabicyclo-[3.2.0]hept-2-ene-2-carboxylic acid

3-Pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene carboxylic acids substituted on the pyrrolidine by unsaturated heterocyclyl have been prepared.

3-Pyrrolidinythio-1-azabicyclo [3.2.0]hept-2-ene-2-carboxylic acid compounds which have antimicrobial activity have been prepared.

3-Pyrrolidinylthio-1-azabicyclo [320] hept-2-ene-2-carboxylic acid anti-microbiotic compounds are prepared.

3-pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

This invention consists of 3-pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds and their use as antimicrobial agents in the treatment of infectious diseases.

Growing community of inventors

Toyonaka, Japan

Takashi Nakajima