Asahi Kasei Kogyo Kabushiki Kaisha

University of Tsukuba

Takashi Nagahara

Hiroshi Nagase

Susumu Imai

Takehiro Shibuya

The present invention aims to provide a novel low-molecular-weight compound having an orexin agonist activity, which is expected to be useful as a superior agent for the treatment or prophylaxis of narcolepsy. The present invention provides a compound showing superior orexin agonist activity which is represented by the formula (I) wherein each symbol is as defined in the DESCRIPTION, and a pharmaceutically acceptable acid addition salt thereof, as well as an orexin agonist containing the compound or a pharmaceutically acceptable acid addition salt thereof.

Sulfonamide derivative or pharmaceutically acceptable acid addition salt thereof

A process for producing a foamable thermoplastic resin article having a relatively thin non-foamed outer shell with a smooth surface and a foamed core portion, which has excellent dimensional stability, by pressurizing a mold cavity under a pressure of gas less than the foaming pressure and not less than the surface smoothing pressure of the foamable resin and permitting the pressure of the gas simultaneously with completion of the injection to be communicated to an atmospheric pressure or lower.

Growing community of inventors

Yokohama, Japan

Takashi Nagahara