Shionogi Company Limited

Takashi Mitsugi

Eiji Kondo

Ryonosuke Muneyuki

Tamio Fujiwara

Kenzo Koizumi

Yoshiharu Wakisaka

A process for producing 6-aminopenicillanic acid and 6-aminopenicillanic acid S-oxide by means of enzymes produced by microbes belonging to Arthrobacter genus, especially Arthrobacter cremorum and Arthrobacter flagellum.

Process for producing 6-aminopenicillanic acid and 6-aminopenicillanic

Penicillins and cephalosporins can be synthesized by the action of an acylase on a penicillin or cephalosporin nucleus amine as substrate and an ester (I) of the following formula as the acyl source: ##STR1## (wherein RCO is an acyl group in penicillin or cephalosporin side chains;

Enzymatic synthesis of .beta.-lactam antibacterials

Penicillin or cephalosporin antibiotics represented by following formula: ##STR1## where ##STR2## is an acyl group derived from an .alpha.-amino acid, N-ammonium salt of .alpha.-amino acid, or N--(C.sub.1 to C.sub.10) acyl-.alpha.-amino acid; COOM is carboxy or carboxylate salt group! Are prepared by treating an amino compound selected from a group consisting of 6-aminopenicillanic acid, 7-aminocephalosporanic acid, 7-aminodeacetoxycephalosporanic acid, and their salts with an ester represented by following formula:

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Izumiotsu, Japan

Takashi Mitsugi