Sumitomo Chemical Company, Limited

Genentech, Inc.

Daiichi Sankyo Company, Limited

Takashi Miki

Isao Kurimoto

Toshiya Takahashi

Shinzo Seko

Tetsuya Ikemoto

Hideki Ushio

Norihiko Hirata

Mark E Reynolds

Srinivasan Babu

Qingping Tian

Zhigang Cheng

Masahiro Takeda

Toshiaki Aikawa

Yasuharu Shimasaki

Keisuke Hatakeyama

Tetsuro Yamazaki

The present invention relates to a method for manufacturing a boronic acid ester compound, characterized by reacting an aryl halide compound and a diboron ester compound in the presence of a nitrogen-containing organic base, a nickel catalyst, a phosphine compound and a solvent. According to the manufacturing method of the present invention, even if a nickel catalyst is used as the catalyst, a desired boronic acid ester compound can be obtained in a sufficiently high yield. Furthermore, even if aryl chloride or aryl bromide having relatively low price and low reactivity, was used as the aryl halide compound, a desired boronic acid ester compound can be obtained in a sufficiently high yield.

Method for manufacturing a boronic acid ester compound

Provided is a new crystal A of optically active 4-amino-3-(4-chlorophenyl)butanoic acid which is far better in stability, and a process for producing the crystal and a process for producing the crystal A comprising a step of heating the following crystal B in water having a pH of 3 to 9:

Optically active 4-amino-3-(4-chlorophenyl)butanoic acid

The present invention provides a method for producing (1S,2R)-2-chloro-2-fluorocyclopropanecarboxylic acid with a high yield and high selectivity. Specifically, disclosed is a method for producing (1S,2R)-2-chloro-2-fluorocyclopropanecarboxylic acid, wherein (1S)-2-chloro-2-fluorocyclopropanecarboxylic acid ester is hydrolyzed using an esterase derived from

Method for producing (1S,2R)-2-chloro-2-fluorocyclopropanecarboxylic acid

There is disclosed an advantageous mixed acid anhydride production method of formula (1):RC(O)OY(O)(R)&#x2003;&#x2003;(1)wherein R, Rand Y denote the same as defined below, n and p denote an integer of 1 or 2, which is characterized by adding a carboxylic acid of formula (2);RCOOH&#x2003;&#x2003;(2)wherein Rdenotes a hydrogen atom, an optionally substituted alkyl group or the like, an organic base to a solution of a carboxylic acid activating agent of formula (3);(R)Y(O)X&#x2003;&#x2003;(3)wherein Rdenotes an optionally substituted aliphatic hydrocarbyl group or the like, Y denotes a carbon atom, a phosphorus atom, or a sulfur atom, and X denotes a chlorine atom or the like.

Production of mixed acid anhydride and amide compound

Vitamin a related compounds and process for producing the same

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Toyonaka, Japan

Takashi Miki