Chugai Seiyaku Kabushiki Kaisha

Takashi Matsuno

Sakae Takaku

Takashi Mori

Minoru Shindo

Yasushi Murakami

Shigeyuki Kataoka

Shigeru Takanashi

Yasuhisa Takeda

Tamotsu Yamazaki

Koji Mizuno

Shun-Ichi Hata

Yoshiyuki Ohsugi

Hiroki Mitsui

Fumiaki Matsuura

Isao Matsunaga

Yasuhiro Yamashita

Yoshimitsu Iida

Kiyoshige Ochi

Shun-ichi Hata

Haruki Ogawa

Hiroshi Okazaki

Toshichika Ogasawara

Kazuo Igusa

Teizo Shinozaki

Yasuho Nishii

Kiyoshige Wakabayashi

Katsuhito Miyamoto

Tsutomu Kawaguchi

Yukifumi Noda

Yutaka Sugawara

Masayoshi Ono

Hiroshi Nakakimura

Mitsuaki Handa

Akira Okazaki

Tomohiro Neichi

Mitsuru Tanemura

Shogo Tomizawa

Yoshiyuki Osugi

Yumiko Takeda

Shinichi Kaiho

Hisako Masuda

Mihoko Ohtaka

Yumiko Tsuruma

Akiko Ariga

Toshiaki Nakano

Novel uracil derivatives of the formula ##STR1## (wherein R.sub.1, R.sub.2 R.sub.3 and X are defined in the description) and their pharmaceutically acceptable salts, process for preparing the same and pharmaceutical composition containing the same are disclosed. The uracil derivatives have good antitumor activity and, therefore, are useful as antitumor preparation.

Novel uracil derivatives, process for preparing the same and a

Novel compound, 1,2-bis(nicotinamido)propane and its pharmaceutically acceptable salts, a process for preparing the same and a pharmaceutical composition containing the same as an active ingredient are disclosed. The compound acts to prevent or spasmolyse cerebral vasospasms, to prevent cerebral apoplexy and to lower the lipoperoxide level in blood.

Nicotinamide derivative, process for preparing the same and

1,4,5,6-Tetrahydronicotinamide derivative represented by the formula: ##STR1## (wherein R is defined in the specification), a process of preparing the same and pharmaceutical composition containing the same are disclosed. The compound has action for suppressing aggregation of platelets, and antiinflammatory, antipyretic and analgesic actions.

Tetrahydronicotinamide derivative, pharmaceutical compositions and use

An anti-tumor preparation containing cells of Streptococcus equisimilis and a process for preparing the preparation which comprises subjecting the cells to heat treatment in a salt solution with or without penicillin treatment.

Anti-tumor preparation against certain tumors and process for preparing

A terephthalic acid monoamide derivative of the formula: ##STR1## (wherein R is a straight- or branched-chain lower alkyl group; R' and R' may be the same or different, and represent a hydrogen atom, or a straight- or branched-chain lower alkyl group) or pharmaceutically acceptable salts thereof are disclosed. A process for preparing such terephthalic acid monoamide derivative or its salts, as well as an anti-allergic agent containing such derivative or its salts as an effective ingredient are also disclosed.

Terephthalic acid monoamide derivatives, process for preparing the same,

An aminobenzoic acid derivative represented by the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are defined hereinbelow, which has excellent activity for improving liver function and for potentiating and normalizing immunity; a process for preparing the same; and a pharmaceutical composition containing the same are disclosed.

Novel aminobenzoic acid derivatives, process for preparing the same and

A bis(benzamido)-benzoic acid derivative represented by the formula ##SPC1## Wherein R.sup.1, R.sup.2 and R.sup.3 are as defined hereinbelow and a process for preparing the same is disclosed. The compounds of the invention inhibit hemolysis of sheep red blood cell and cutaneous anaphylactic reaction, and also have an antipyretic sedative, anti-inflammatory and anti-allergic effect and are especially useful for treatment of rheumatic arthritis, bronchial asthma and nephritis.

Bis(benzamido)-benzoic acid derivatives

Growing community of inventors

Omiya, Japan

Takashi Matsuno