Nof Corporation

Takashi Matani

Hiroki Yoshioka

Yuji Yamamoto

Shuichi Yoshimura

Kazuhiro Hashimoto

A polyoxyethylene derivative represented by the formula (1): wherein a whole molecular weight of the polyoxyethylene derivative is 500 to 160,000; n is 5 to 3650; L, L, and Leach independently represent an alkylene group, a phenylene group, an ester bond, an amide bond, an ether bond, a urethane bond, a carbonate bond, a secondary amino group, or a combination thereof; X represents a functional group capable of reacting with a bio-related substance; Y represents a hydrophilic group having plural hydroxyl groups made from a residual group of xylitol or volemitol or a residual group of polyglycerin of trimer to 31-mer; Z represents a residual group of a compound having 2 to 5 active hydrogen atoms; b and c are as follows: 1&#x2266;b&#x2266;4, 1&#x2266;c&#x2266;4, and 2&#x2266;b+c&#x2266;5; and d and e each independently are 0 or 1.

Polyoxyethylene derivative having plural hydroxyl groups at terminal end thereof

A method for producing a polyoxyalkylene derivative including: step (A) in which a polyoxyalkylene derivative having hydroxyl group(s) is reacted with a phthalimide derivative in the presence of an azo reagent and a phosphine reagent; step (B) in which the phthalimide groups of the compound obtained in step (A) are deprotected using a compound having a primary amino group; and step (C) in which impurities derived from the phthalimide derivative and the deprotection reagent are removed by adsorption or extraction.

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Kanagawa, Japan

Takashi Matani